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The main characteristic of this condition is a profound loss of muscle mass. <jats:italic>Methods<\/jats:italic>: By using a microarray system, expression of several hundred genes was screened in skeletal muscle of rats bearing a cachexia\u2010inducing tumor, the AH\u2010130 Yoshida ascites hepatoma. This model induced a strong decrease in muscle mass in the tumor\u2010bearing animals, as compared with their healthy counterparts. <jats:italic>Results<\/jats:italic>: The results show important differences in gene expression in EDL skeletal muscle between tumor\u2010bearing animals with cachexia and control animals. <jats:italic>Conclusions<\/jats:italic>: The differences observed pertain to genes related to intracellular calcium homeostasis and genes involved in the control of mitochondrial oxidative phosphorylation and protein turnover, both at the level of protein synthesis and proteolysis. Assessment of these differences may be a useful tool for the design of novel therapeutic strategies to fight this devastating syndrome. <jats:italic>Muscle Nerve<\/jats:italic> <jats:bold>49<\/jats:bold>: 233\u2013248, 2014<\/jats:p>","DOI":"10.1002\/mus.23893","type":"journal-article","created":{"date-parts":[[2013,5,4]],"date-time":"2013-05-04T05:16:43Z","timestamp":1367644603000},"page":"233-248","source":"Crossref","is-referenced-by-count":19,"title":["A differential pattern of gene expression in skeletal muscle of tumor\u2010bearing rats reveals dysregulation of excitation\u2013contraction coupling together with additional muscle alterations"],"prefix":"10.1002","volume":"49","author":[{"given":"Cibely Cristine","family":"Fontes\u2010Oliveira","sequence":"first","affiliation":[{"name":"Cancer Research Group, Departament de Bioqu\u00edmica i Biologia Molecular, Facultat de Biologia Universitat de Barcelona Diagonal 643 Barcelona 08028 Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00edlvia","family":"Busquets","sequence":"additional","affiliation":[{"name":"Cancer Research Group, Departament de Bioqu\u00edmica i Biologia Molecular, Facultat de Biologia Universitat de Barcelona Diagonal 643 Barcelona 08028 Spain"},{"name":"Institut de Biomedicina de la Universitat de Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gemma","family":"Fuster","sequence":"additional","affiliation":[{"name":"Cancer Research Group, Departament de Bioqu\u00edmica i Biologia Molecular, Facultat de Biologia Universitat de Barcelona Diagonal 643 Barcelona 08028 Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabet","family":"Ametller","sequence":"additional","affiliation":[{"name":"Cancer Research Group, Departament de Bioqu\u00edmica i Biologia Molecular, Facultat de Biologia Universitat de Barcelona Diagonal 643 Barcelona 08028 Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maite","family":"Figueras","sequence":"additional","affiliation":[{"name":"Cancer Research Group, Departament de Bioqu\u00edmica i Biologia Molecular, Facultat de Biologia Universitat de Barcelona Diagonal 643 Barcelona 08028 Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mireia","family":"Olivan","sequence":"additional","affiliation":[{"name":"Cancer Research Group, Departament de Bioqu\u00edmica i Biologia Molecular, Facultat de Biologia Universitat de Barcelona Diagonal 643 Barcelona 08028 Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00edriam","family":"Toledo","sequence":"additional","affiliation":[{"name":"Cancer Research Group, Departament de Bioqu\u00edmica i Biologia Molecular, Facultat de Biologia Universitat de Barcelona Diagonal 643 Barcelona 08028 Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco J.","family":"L\u00f3pez\u2010Soriano","sequence":"additional","affiliation":[{"name":"Cancer Research Group, Departament de Bioqu\u00edmica i Biologia Molecular, Facultat de Biologia Universitat de Barcelona Diagonal 643 Barcelona 08028 Spain"},{"name":"Institut de Biomedicina de la Universitat de Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Qu","sequence":"additional","affiliation":[{"name":"Procter &amp; 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