{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T17:40:30Z","timestamp":1777052430158,"version":"3.51.4"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,6,26]],"date-time":"2013-06-26T00:00:00Z","timestamp":1372204800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p><jats:italic>Introduction<\/jats:italic>: An 80\u2010year\u2010old man had a 40\u2010year history of chronic sensory ataxic neuropathy and 11 years of relapsing\/remitting episodes of rapid deterioration with perioral paresthesiae and weakness of bulbar, respiratory, and limb muscles. <jats:italic>Methods<\/jats:italic>: An immunoglobulin M (IgM) paraprotein was detected 12 years before death, and Waldenstrom macroglobulinemia was diagnosed on bone marrow biopsy 3 years before death. Chronic ataxic neuropathy with ophthalmoplegia, IgM paraprotein, cold agglutinins, and anti\u2010disialyl antibodies (CANOMAD) was diagnosed. <jats:italic>Results<\/jats:italic>: Comprehensive autopsy showed severe dorsal column atrophy and dorsal root ganglionopathy. A different pathology was identified in cranial and peripheral nerves, dorsal roots, and cauda equina, comprising infiltration of clonal B\u2010lymphocytes within the endoneurium, perineurium, and leptomeninges. <jats:italic>Conclusions<\/jats:italic>: The autopsy provides evidence of the pathogenesis of the relapsing remitting component of CANOMAD, and we postulate that this may relate to the presence of clonal IgM anti\u2010disiayl gangliosides secreting B\u2010lymphocytes within nerves. <jats:italic>Muscle Nerve<\/jats:italic> <jats:bold>48<\/jats:bold>: 599\u2013603, 2013<\/jats:p>","DOI":"10.1002\/mus.23897","type":"journal-article","created":{"date-parts":[[2013,5,6]],"date-time":"2013-05-06T08:04:44Z","timestamp":1367827484000},"page":"599-603","source":"Crossref","is-referenced-by-count":19,"title":["Canomad: report of a case with a 40\u2010year history and autopsy. Is this a sensory ganglionopathy with neuromuscular junction blockade?"],"prefix":"10.1002","volume":"48","author":[{"given":"Penelope A.","family":"Mckelvie","sequence":"first","affiliation":[{"name":"Department of Anatomical Pathology St. Vincent's Hospital Melbourne PO Box 2900, Fitzroy, Victoria 3065 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter C.","family":"Gates","sequence":"additional","affiliation":[{"name":"Department of Neuroscience Geelong Hospital Geelong VIC"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy","family":"Day","sequence":"additional","affiliation":[{"name":"Department of Neurology Royal Melbourne Hospital Melbourne Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,6,26]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410180605"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.42.3.686"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118529"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/124.10.1968"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4598(199910)22:10<1426::AID-MUS13>3.0.CO;2-H"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410390404"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8249(199903)45:3<400::AID-ANA19>3.0.CO;2-Y"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh231"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awm316"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(98)00985-9"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2009.171702"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.61.7.1013"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-010-0783-x"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2010.230532"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-05-174359"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1053\/sonc.2003.50082"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.61.9.1307"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2007.120444"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-008-0803-0"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-009-5071-0"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.22157"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.20452"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-009-5412-z"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.22167"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1529-8027.2012.00376.x"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2005.071175"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1999.01482.x"},{"key":"e_1_2_5_29_1","first-page":"353","article-title":"Nervous system lymphoid infiltration in Waldenstrom's macroglobulinemia","volume":"62","author":"Massengo S","year":"2003","journal-title":"A case report. 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