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Pretreatment data provide insight into reliability, concurrent validity, and minimal clinically important differences (MCIDs) of the 6\u2010minute walk test (6MWT) and other endpoints. Methods: Screening and baseline evaluations included the 6\u2010minute walk distance (6MWD), timed function tests (TFTs), quantitative strength by myometry, the PedsQL, heart rate\u2013determined energy expenditure index, and other exploratory endpoints. Results: The 6MWT proved feasible and reliable in a multicenter context. Concurrent validity with other endpoints was excellent. The MCID for 6MWD was 28.5 and 31.7 meters based on 2 statistical distribution methods. Conclusions: The ratio of MCID to baseline mean is lower for 6MWD than for other endpoints. The 6MWD is an optimal primary endpoint for Duchenne muscular dystrophy (DMD) clinical trials that are focused therapeutically on preservation of ambulation and slowing of disease progression. <jats:italic>Muscle Nerve<\/jats:italic> <jats:bold>48<\/jats:bold>: 357\u2013368, 2013<\/jats:p>","DOI":"10.1002\/mus.23905","type":"journal-article","created":{"date-parts":[[2013,5,14]],"date-time":"2013-05-14T11:20:44Z","timestamp":1368530444000},"page":"357-368","source":"Crossref","is-referenced-by-count":309,"title":["The 6\u2010minute walk test and other clinical endpoints in duchenne muscular dystrophy: Reliability, concurrent validity, and minimal clinically important differences from a multicenter study"],"prefix":"10.1002","volume":"48","author":[{"given":"Craig M.","family":"McDonald","sequence":"first","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation Neuromuscular Medicine and Rehabilitation Research Center, University of California Davis School of Medicine Davis California 95817 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik K.","family":"Henricson","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation Neuromuscular Medicine and Rehabilitation Research Center, University of California Davis School of Medicine Davis California 95817 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. 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