{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T13:18:23Z","timestamp":1782998303822,"version":"3.54.5"},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,12,17]],"date-time":"2013-12-17T00:00:00Z","timestamp":1387238400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"The National Institutes of Health (NIH) Grants to CJK","award":["K08 NS065007-01A1, NS36797"],"award-info":[{"award-number":["K08 NS065007-01A1, NS36797"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p><jats:italic>Introduction<\/jats:italic>: We investigated the clinical, electrophysiological and neural autoantibody characteristics in cramp\u2010fasciculation syndrome (CFS) patients. <jats:italic>Methods<\/jats:italic>: We reviewed Mayo Clinic records from 2000 to 2011 to identify clinically defined CFS patients who underwent neural autoantibody testing. Stored sera of patients who tested positive for antibodies to voltage\u2010gated potassium channel complex (VGKC complex) were analyzed further for leucine\u2010rich glioma\u2010inactivated 1 (LGI1) or contactin\u2010associated protein\u20102 immunoglobulin G (CASPR2\u2010IgG) antibodies. <jats:italic>Results<\/jats:italic>: Thirty\u2010seven patients were identified. Twelve were seropositive for neural autoantibodies. Clinical manifestations were similar in seropositive and seronegative patients, although central and autonomic neuronal hyperexcitability symptoms were more common in seropositive cases. No patients had a malignancy. Repetitive tibial nerve stimulation at 10 Hz revealed longer afterdischarges in seropositive patients. Two of 7 patients with VGKC\u2010complex autoimmunity demonstrated LGI1 or CASPR2\u2010IgG antibodies. Only 2 of 12 seropositive patients required immunotherapy. <jats:italic>Conclusions<\/jats:italic>: VGKC\u2010complex autoimmunity occurs in a minority of CFS patients. Antibody positivity was associated with extramuscular manifestations, typically without malignancy. Target antigens within the VGKC complex remain unknown in most patients. <jats:italic>Muscle Nerve<\/jats:italic> <jats:bold>49<\/jats:bold>:351\u2013356, 2014<\/jats:p>","DOI":"10.1002\/mus.23935","type":"journal-article","created":{"date-parts":[[2013,7,8]],"date-time":"2013-07-08T12:13:30Z","timestamp":1373285610000},"page":"351-356","source":"Crossref","is-referenced-by-count":42,"title":["Cramp\u2010fasciculation syndrome in patients with and without neural autoantibodies"],"prefix":"10.1002","volume":"49","author":[{"given":"Teerin","family":"Liewluck","sequence":"first","affiliation":[{"name":"Department of Neurology Mayo Clinic 200 First Street SW Rochester Minnesota 55905 USA"},{"name":"Department of Neurology University of Colorado School of Medicine Anschutz Medical Campus Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher J.","family":"Klein","sequence":"additional","affiliation":[{"name":"Department of Neurology Mayo Clinic 200 First Street SW Rochester Minnesota 55905 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Lyell K.","family":"Jones","sequence":"additional","affiliation":[{"name":"Department of Neurology Mayo Clinic 200 First Street SW Rochester Minnesota 55905 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,12,17]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410150104"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNP.0b013e3181968f00"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.41.7.1021"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182061b1e"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.42.9.1845-d"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410380505"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.54.3.771"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.10266"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awf178"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000312275.04260.a0"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.1097"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(10)70137-X"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awq213"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22297"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.23577"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20269"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.21653"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182698cab"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410410215"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2013.592"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/CND.0b013e318246197d"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2011.2985"}],"container-title":["Muscle &amp; Nerve"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmus.23935","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmus.23935","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.23935","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T12:44:03Z","timestamp":1736426643000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mus.23935"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12,17]]},"references-count":22,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,3]]}},"alternative-id":["10.1002\/mus.23935"],"URL":"https:\/\/doi.org\/10.1002\/mus.23935","archive":["Portico"],"relation":{},"ISSN":["0148-639X","1097-4598"],"issn-type":[{"value":"0148-639X","type":"print"},{"value":"1097-4598","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,12,17]]}}}