{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T19:28:06Z","timestamp":1791401286604,"version":"4.3.3"},"reference-count":19,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,2,4]],"date-time":"2014-02-04T00:00:00Z","timestamp":1391472000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Introduction<\/jats:italic>\n                    : The minimal clinically important difference (MCID) is the smallest outcome change that has clinical significance. Its use has not been established in the study of myasthenia gravis (MG).\n                    <jats:italic>Methods<\/jats:italic>\n                    : Patients from a published intravenous immunoglobulin (IVIg) vs. placebo study were studied. One anchor\u2010based and 3 distribution\u2010based techniques were used to identify quantitative myasthenia gravis score (QMGS), repetitive nerve stimulation (RNS), and single\u2010fiber electromyography (SFEMG) MCID cut\u2010offs. Patients with a change\u2010score exceeding MCID cut\u2010offs were compared.\n                    <jats:italic>Results<\/jats:italic>\n                    : MCID cut\u2010offs were below a QMGS change of 3.0. Anchor\u2010based and 1 \u00d7 SEM cut\u2010offs showed 58.3% vs. 30.7% responders (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.017), \u00bd SD 54.2% vs. 19.2% responders (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.018), and effect size 0.519 vs. 0.164 (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.011) in IVIg vs. placebo. Anchor\u2010based (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.73) and effect\u2010size (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.41) MCID cut\u2010offs did not show a difference between IVIg and placebo. MCID methods did not produce meaningful RNS cut\u2010offs.\n                    <jats:italic>Conclusions<\/jats:italic>\n                    : QMGS MCID values provide clinically relevant information and are recommended in MG trials. MCID analysis shows that improvement in MG patients treated with IVIg reflects clinically meaningful changes.\n                    <jats:italic>Muscle Nerve<\/jats:italic>\n                    <jats:bold>49<\/jats:bold>\n                    : 661\u2013665, 2014\n                  <\/jats:p>","DOI":"10.1002\/mus.23988","type":"journal-article","created":{"date-parts":[[2013,8,12]],"date-time":"2013-08-12T06:26:55Z","timestamp":1376288815000},"page":"661-665","source":"Crossref","is-referenced-by-count":84,"title":["Minimal clinically important difference in myasthenia gravis: Outcomes from a randomized trial"],"prefix":"10.1002","volume":"49","author":[{"given":"Hans D.","family":"Katzberg","sequence":"first","affiliation":[{"name":"University Health Network, Division of Neurology Toronto General Hospital 200 Elizabeth Street, 5ES\u2010306 Toronto Ontario M5G 2C4 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Barnett","sequence":"additional","affiliation":[{"name":"University Health Network, Division of Neurology Toronto General Hospital 200 Elizabeth Street, 5ES\u2010306 Toronto Ontario M5G 2C4 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingemar S.J.","family":"Merkies","sequence":"additional","affiliation":[{"name":"Department of Neurology Spaarne Hospital, Hoofddorp and Maastricht University Medical Centre Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vera","family":"Bril","sequence":"additional","affiliation":[{"name":"University Health Network, Division of Neurology Toronto General Hospital 200 Elizabeth Street, 5ES\u2010306 Toronto Ontario M5G 2C4 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,2,4]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000256698.69121.45"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1998.tb11015.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1017\/CBO9780511996214"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0197-2456(89)90005-6"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2009.194324"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0895-4356(94)90036-1"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.spinee.2007.11.006"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1586\/erp.11.9"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1475-6773.2005.0l374.x"},{"key":"e_1_2_6_11_1","first-page":"231926","article-title":"Definition of nonresponse to analgesic treatment of arthritic pain: an analytical literature review of the smallest detectable difference, the minimal detectable change, and the minimal clinically important difference on the pain visual analog scale","author":"Stauffer ME","year":"2011","journal-title":"Int J Inflam"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2004.022905"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.20419"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.23236"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4598(199609)19:9<1069::AID-MUS1>3.0.CO;2-Y"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880150513"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-004-7713-0"},{"key":"e_1_2_6_18_1","volume-title":"Probabilistic models for some intelligence and attainment tests","author":"Rasch G","year":"1980"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awr318"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181dc1b1e"}],"container-title":["Muscle &amp; Nerve"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmus.23988","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmus.23988","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.23988","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T11:14:40Z","timestamp":1696331680000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mus.23988"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2,4]]},"references-count":19,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,5]]}},"alternative-id":["10.1002\/mus.23988"],"URL":"https:\/\/doi.org\/10.1002\/mus.23988","archive":["Portico"],"relation":{},"ISSN":["0148-639X","1097-4598"],"issn-type":[{"value":"0148-639X","type":"print"},{"value":"1097-4598","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,2,4]]}}}