{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T07:32:50Z","timestamp":1790839970400,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,5,5]],"date-time":"2014-05-05T00:00:00Z","timestamp":1399248000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000005","name":"The Department of Defense","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100014055","name":"USAMRAA","doi-asserted-by":"crossref","award":["09131005(W81XWH-10-1-0127)"],"award-info":[{"award-number":["09131005(W81XWH-10-1-0127)"]}],"id":[{"id":"10.13039\/100014055","id-type":"DOI","asserted-by":"crossref"}]},{"name":"The SMA Foundation"},{"name":"AKR received research support from NICHD","award":["K01 HD060912"],"award-info":[{"award-number":["K01 HD060912"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p><jats:italic>Introduction<\/jats:italic>: Spinal muscular atrophy (SMA) causes muscle weakness and fatigue. Better understanding of the relationship between weakness and fatigue may help identify potential targets for rehabilitation. <jats:italic>Methods<\/jats:italic>: Gait and surface electromyography (EMG) from 4 muscle groups were measured during the Six\u2010Minute Walk Test (6MWT) in 10 ambulatory participants, aged 9\u201349 years. Average root mean square amplitude (RMS) of muscle activity was calculated. Strength was assessed using manual and quantitative methods. <jats:italic>Results<\/jats:italic>: RMS, stride length, and velocity decreased during the 6MWT. Knee flexor and hip abductor strength was associated with fatigue\u2010related changes; overall strength correlated with disease duration; and leg strength was associated with 6MWT distance. <jats:italic>Conclusions<\/jats:italic>: Clinical measures are valid in assessing fatigue and function in SMA, and these assessments can be enhanced by use of gait analysis and EMG. Disease duration and strength measures may represent further stratification refinements when enrolling patients in clinical trials. <jats:italic>Muscle Nerve<\/jats:italic> <jats:bold>50<\/jats:bold>: 34\u201339, 2014<\/jats:p>","DOI":"10.1002\/mus.24081","type":"journal-article","created":{"date-parts":[[2013,10,12]],"date-time":"2013-10-12T01:14:50Z","timestamp":1381540490000},"page":"34-39","source":"Crossref","is-referenced-by-count":40,"title":["Leg muscle function and fatigue during walking in spinal muscular atrophy type 3"],"prefix":"10.1002","volume":"50","author":[{"given":"Jacqueline","family":"Montes","sequence":"first","affiliation":[{"name":"Department of Neurology Columbia University 180 Fort Washington Avenue, 5th Floor New York NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sally","family":"Dunaway","sequence":"additional","affiliation":[{"name":"Department of Neurology Columbia University 180 Fort Washington Avenue, 5th Floor New York NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol Ewing","family":"Garber","sequence":"additional","affiliation":[{"name":"Department of Biobehavioral Sciences, Teachers College Columbia University New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia A.","family":"Chiriboga","sequence":"additional","affiliation":[{"name":"Department of Neurology Columbia University 180 Fort Washington Avenue, 5th Floor New York NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darryl C.","family":"De Vivo","sequence":"additional","affiliation":[{"name":"Department of Neurology Columbia University 180 Fort Washington Avenue, 5th Floor New York NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashwini K.","family":"Rao","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation and Regenerative Medicine (Program in Physical Therapy), and G.H. Sergievsky Center Columbia University Medical Center New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,5,5]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"145","volume-title":"Neuromuscular disorders of infancy, childhood, and adolescence: a clinician's approach","author":"Crawford TO","year":"2003"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/16501970510030156"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-8966(97)00113-2"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000324623.89105.c4"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gaitpost.2004.04.006"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31827f07be"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/088307389701200507"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181d3e308"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.21917"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1050-6411(02)00050-0"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.166.1.at1102"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2007.05.009"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/0883073813493663"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9290(01)00105-1"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2008.10.107"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.09.011"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.22211"},{"key":"e_1_2_7_19_1","first-page":"251","article-title":"Myoelectrical manifestations of localized muscular fatigue in humans","volume":"11","author":"Luca CJ","year":"1984","journal-title":"Crit Rev Biomed Eng"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1994.74.1.49"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1050-6411(02)00083-4"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gaitpost.2007.11.004"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1191\/0269215505cr873oa"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e318271f7e4"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-510X(96)00284-5"}],"container-title":["Muscle &amp; Nerve"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmus.24081","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmus.24081","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.24081","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T01:26:51Z","timestamp":1696382811000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mus.24081"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5,5]]},"references-count":24,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,7]]}},"alternative-id":["10.1002\/mus.24081"],"URL":"https:\/\/doi.org\/10.1002\/mus.24081","archive":["Portico"],"relation":{},"ISSN":["0148-639X","1097-4598"],"issn-type":[{"value":"0148-639X","type":"print"},{"value":"1097-4598","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,5,5]]}}}