{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T00:02:07Z","timestamp":1778976127389,"version":"3.51.4"},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,6,19]],"date-time":"2014-06-19T00:00:00Z","timestamp":1403136000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p><jats:italic>Introduction<\/jats:italic>: Wallerian degeneration (WD) is an important area of research in modern neuroscience. Many protein expressions are regulated by differentially expressed genes in WD, but the precise mechanisms are elusive. <jats:italic>Methods<\/jats:italic>: In this study, we profiled differentially expressed proteins in WD after rat sciatic nerve injury using an antibody array. <jats:italic>Results<\/jats:italic>: Functional analysis positively identified cell proliferation, regulation of cell proliferation, and immune system processes. Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis revealed molecular networks related mainly to cytokine\u2013cytokine receptor interaction, the mitogen\u2010activated proteinkinase (MAPK) signaling pathway, apoptosis, the toll\u2010like receptor (TLR) signaling pathway, and the Janus kinase (Jak) \u2010 signal transducer and activator of transcription (STAT) signaling pathway. Interactions between these differential proteins were well established and regulated by the key factors transforming growth factor beta 1 (TGF\u2010\u03b21), toll\u2010like receptor 4 (TLR4), Fas ligand (FasL), and 5\u2032\u2010AMP\u2010activated protein kinase catalytic subunit alpha\u20101 (PRKAA1). <jats:italic>Conclusions<\/jats:italic>: These results provide information related to functional analysis of differentially expressed genes during WD. <jats:italic>Muscle Nerve<\/jats:italic> <jats:bold>50<\/jats:bold>: 73\u201378, 2014<\/jats:p>","DOI":"10.1002\/mus.24082","type":"journal-article","created":{"date-parts":[[2013,10,12]],"date-time":"2013-10-12T01:29:26Z","timestamp":1381541366000},"page":"73-78","source":"Crossref","is-referenced-by-count":23,"title":["Protein expression profiling during wallerian degeneration after rat sciatic nerve injury"],"prefix":"10.1002","volume":"50","author":[{"given":"Meiyuan","family":"Li","sequence":"first","affiliation":[{"name":"Jiangsu Key Laboratory of Neuroregeneration Nantong University Nantong Jiangsu P.R. 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