{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T09:30:51Z","timestamp":1759483851466},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,5,5]],"date-time":"2014-05-05T00:00:00Z","timestamp":1399248000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p><jats:italic>Introduction<\/jats:italic>: Anoctamin 5 deficiency has recently been defined to cause limb\u2010girdle muscular dystrophy type 2L (LGMD2L) with pronounced hyperCKemia. No treatment interventions have been made so far in this condition. <jats:italic>Methods<\/jats:italic>: In 6 patients with LGMD2L, we studied the effect of home\u2010based, pulse\u2010watch monitored, moderate\u2010intensity exercise on a cycle ergometer for 30 minutes, 3 times weekly, for 10 weeks. Plasma creatine kinase (CK) was assessed before, during, and after the program as a marker of muscle damage. Primary outcome measures were maximum oxygen uptake (VO<jats:sub>2max<\/jats:sub>) and time in the 5\u2010repetitions\u2010sit\u2010to\u2010stand test (FRSTST). <jats:italic>Results<\/jats:italic>: Training resulted in improvements in VO<jats:sub>2max<\/jats:sub> (27\u2009\u00b1\u20097%; <jats:italic>P<\/jats:italic>\u2009=\u20090.0001) and FRSTST time (35\u2009\u00b1\u200912%; <jats:italic>P<\/jats:italic>\u2009=\u20090.007). Improvements in physiologic and functional muscle testing were accompanied by stable CK levels and no reports of adverse effects. <jats:italic>Conclusions<\/jats:italic>: These findings suggest that supervised aerobic exercise training is safe and effective in improving oxidative capacity and muscle function in patients with anoctamin 5 deficiency. <jats:italic>Muscle Nerve<\/jats:italic> <jats:bold>50<\/jats:bold>: 119\u2013123, 2014<\/jats:p>","DOI":"10.1002\/mus.24112","type":"journal-article","created":{"date-parts":[[2013,11,6]],"date-time":"2013-11-06T19:03:30Z","timestamp":1383764610000},"page":"119-123","source":"Crossref","is-referenced-by-count":18,"title":["Aerobic training in patients with anoctamin 5 myopathy and hyperckemia"],"prefix":"10.1002","volume":"50","author":[{"given":"Christoffer R.","family":"Vissing","sequence":"first","affiliation":[{"name":"Neuromuscular Research Unit, Department of Neurology, Section 3342, Rigshospitalet University of Copenhagen Blegdamsvej 9, DK\u20102100 Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolai","family":"Preisler","sequence":"additional","affiliation":[{"name":"Neuromuscular Research Unit, Department of Neurology, Section 3342, Rigshospitalet University of Copenhagen Blegdamsvej 9, DK\u20102100 Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edith","family":"Husu","sequence":"additional","affiliation":[{"name":"Neuromuscular Research Unit, Department of Neurology, Section 3342, Rigshospitalet University of Copenhagen Blegdamsvej 9, DK\u20102100 Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kira P.","family":"Prahm","sequence":"additional","affiliation":[{"name":"Neuromuscular Research Unit, Department of Neurology, Section 3342, Rigshospitalet University of Copenhagen Blegdamsvej 9, DK\u20102100 Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Vissing","sequence":"additional","affiliation":[{"name":"Neuromuscular Research Unit, Department of Neurology, Section 3342, Rigshospitalet University of Copenhagen Blegdamsvej 9, DK\u20102100 Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,5,5]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2009.12.013"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awq294"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/aps.2011.48"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2007.03.108"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2012.09.070"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2013.03.012"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-013-6934-y"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2012.05.001"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2010.07.270"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31824c4682"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.23281"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.23440"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.23542"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-012-6502-x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2011.07.005"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/humu.22342"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awn189"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000250358.32199.24"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000150584.45055.27"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2012.08.005"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20460"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4598(199909)22:9<1239::AID-MUS11>3.0.CO;2-W"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1519\/JSC.0b013e318234e59f"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2009.10.030"},{"key":"e_1_2_7_26_1","first-page":"1","article-title":"Aerobic work capacity in men and women with special reference to age","volume":"49","author":"Astrand I","year":"1960","journal-title":"Acta Physiol Scand Suppl"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/ptj\/85.10.1034"},{"key":"e_1_2_7_28_1","first-page":"2395","article-title":"Physical fitness and all\u2010cause mortality","volume":"262","author":"Blair SN","year":"1989","journal-title":"A prospective study of healthy men and women. 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