{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T23:36:33Z","timestamp":1776987393985,"version":"3.51.4"},"reference-count":12,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,1,27]],"date-time":"2014-01-27T00:00:00Z","timestamp":1390780800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Our goal in this report was to determine whether symptom progression in primary lateral sclerosis (PLS) was consistent with disease spread through axonal pathways or contiguous cortical regions. The date of symptom onset in each limb and cranial region was obtained from 45 PLS patient charts. Each appearance of symptoms in a new body region was classified as <jats:italic>axonal<\/jats:italic>, <jats:italic>contiguous<\/jats:italic>, <jats:italic>possibly contiguous<\/jats:italic>, or <jats:italic>unrelated<\/jats:italic>, according to whether the somatotopic representations were adjacent in the cortex. Of 152 spread events, the first spread event was equally divided between <jats:italic>axonal<\/jats:italic> (22) and <jats:italic>contiguous<\/jats:italic> (23), but the majority of subsequent spread events were classified as <jats:italic>contiguous<\/jats:italic>. Symptom progression in PLS patients is consistent with disease spread along axonal tracts and by local cortical spread. Both were equally likely for the first spread event, but local cortical spread was predominant thereafter, suggesting that late degeneration does not advance through long axonal tracts. <jats:italic>Muscle Nerve<\/jats:italic> <jats:bold>49<\/jats:bold>:439\u2013441, 2014<\/jats:p>","DOI":"10.1002\/mus.24116","type":"journal-article","created":{"date-parts":[[2013,11,12]],"date-time":"2013-11-12T04:34:58Z","timestamp":1384230898000},"page":"439-441","source":"Crossref","is-referenced-by-count":6,"title":["Disease spread through contiguity and axonal tracts in primary lateral sclerosis"],"prefix":"10.1002","volume":"49","author":[{"given":"Flynn","family":"Lauren","sequence":"first","affiliation":[{"name":"Spasticity and Spinal Physiology Unit National Institute of Neurological Disorders and Stroke, National Institutes of Health Building 10, CRC Room 7\u20105680 Bethesda Maryland 20892\u20101404 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Stephen","sequence":"additional","affiliation":[{"name":"Spasticity and Spinal Physiology Unit National Institute of Neurological Disorders and Stroke, National Institutes of Health Building 10, CRC Room 7\u20105680 Bethesda Maryland 20892\u20101404 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary Kay","family":"Floeter","sequence":"additional","affiliation":[{"name":"Spasticity and Spinal Physiology Unit National Institute of Neurological Disorders and Stroke, National Institutes of Health Building 10, CRC Room 7\u20105680 Bethesda Maryland 20892\u20101404 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,1,27]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)61156-7"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181b6bbbd"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2012-303992"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0013664"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.3109\/21678421.2013.778548"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2011-301826"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.20728"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000200962.94777.71"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.3109\/17482960903171136"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.21936"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.20942"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2011.03616.x"}],"container-title":["Muscle &amp; Nerve"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmus.24116","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmus.24116","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.24116","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T12:44:48Z","timestamp":1736426688000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mus.24116"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1,27]]},"references-count":12,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,3]]}},"alternative-id":["10.1002\/mus.24116"],"URL":"https:\/\/doi.org\/10.1002\/mus.24116","archive":["Portico"],"relation":{},"ISSN":["0148-639X","1097-4598"],"issn-type":[{"value":"0148-639X","type":"print"},{"value":"1097-4598","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1,27]]}}}