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Malignancies, especially small cell lung cancer (SCLC), have been associated with LEMS and account for approximately 60% of cases, making malignancy management a central step in LEMS therapy. In addition, immunosuppressive therapy is also recommended for symptomatic control. Interestingly, both pathological and epidemiological data suggest that the autoimmune response can inhibit progression of tumors in malignancy\u2010associated LEMS. Thus, conventional broad\u2010spectrum immunosuppressants may not be effective agents for treatment of LEMS, especially in those with malignancy\u2010associated LEMS. Recent preclinical and clinical studies have indicated that proteasome inhibitors can eliminate antibody\u2010producing cells efficiently, block dendritic cell maturation, and have anti\u2010tumor activity. We hypothesize that proteasome inhibitors may be promising agents for treatment of malignancy\u2010related LEMS. <jats:italic>Muscle Nerve<\/jats:italic> <jats:bold>49<\/jats:bold>:325\u2013328, 2014<\/jats:p>","DOI":"10.1002\/mus.24122","type":"journal-article","created":{"date-parts":[[2013,11,20]],"date-time":"2013-11-20T10:46:22Z","timestamp":1384944382000},"page":"325-328","source":"Crossref","is-referenced-by-count":2,"title":["Proteasome inhibitors for malignancy\u2010related lambert\u2010eaton myasthenic syndrome"],"prefix":"10.1002","volume":"49","author":[{"given":"Chen","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Medicine Peking Union Medical College, Chinese Academy of Medical Sciences Beijing China"},{"name":"Department of Neurology Peking Union Medical College Hospital, Beijing  China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaobo","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Medicine 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