{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T05:01:08Z","timestamp":1774933268140,"version":"3.50.1"},"reference-count":9,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,4,8]],"date-time":"2014-04-08T00:00:00Z","timestamp":1396915200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>All descriptions of the Lambert\u2013Eaton syndrome are based on symptomatic patients. We incidentally encountered electromyographic evidence of this syndrome in a patient being studied for another reason. The patient had controlled hypothyroidism and smoked for 9 pack\u2010years but never had symptoms of weakness or had evidence of cancer. <jats:italic>Methods<\/jats:italic>: Detailed electrophysiological and serological evaluations were undertaken in this study. <jats:italic>Results<\/jats:italic>: Neuromuscular transmission tests were consistent with a presynaptic disorder. Autoantibodies specific for P\/Q\u2010type voltage\u2010gated calcium channels (VGCC) were detected in the serum and persisted throughout 7 years of follow\u2010up. Multiple IgG markers of thyrogastric autoimmunity also were detected. <jats:italic>Conclusions<\/jats:italic>: This demonstration of asymptomatic Lambert\u2013Eaton syndrome persisting for 8 years provided novel insight into the natural history of the disorder. It is plausible that patients with a subclinical syndrome would have abrupt neuromuscular decompensation when challenged with medications that compromise the safety factor for synaptic transmission. <jats:italic>Muscle Nerve<\/jats:italic> <jats:bold>49<\/jats:bold>: 764\u2013767, 2014<\/jats:p><\/jats:sec>","DOI":"10.1002\/mus.24126","type":"journal-article","created":{"date-parts":[[2013,11,21]],"date-time":"2013-11-21T03:41:17Z","timestamp":1385005277000},"page":"764-767","source":"Crossref","is-referenced-by-count":5,"title":["Asymptomatic lambert\u2013eaton syndrome"],"prefix":"10.1002","volume":"49","author":[{"given":"Eric H.","family":"Denys","sequence":"first","affiliation":[{"name":"Department of Neurosciences California Pacific Medical Center San Francisco California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanda A.","family":"Lennon","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology Mayo Clinic, College of Medicine Rochester Minnesota USA"},{"name":"Department of Neurology Mayo Clinic, College of Medicine Rochester Minnesota USA"},{"name":"Department of Immunology Mayo Clinic, College of Medicine Rochester Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,4,8]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"205","article-title":"Passive transfer of the myasthenic syndrome: a preliminary report","volume":"60","author":"Denys EH","year":"1979","journal-title":"Acta Neurol Scand"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(81)90474-8"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880111105"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199201000-00022"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.52.2.435"},{"key":"e_1_2_5_7_1","first-page":"269","volume-title":"Current clinical neurology: myasthenia gravis and related disorders","author":"Harper CM","year":"2008"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/111.3.577"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000130254.27019.14"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.20332"}],"container-title":["Muscle &amp; Nerve"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmus.24126","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.24126","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T15:15:46Z","timestamp":1696346146000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mus.24126"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,4,8]]},"references-count":9,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,5]]}},"alternative-id":["10.1002\/mus.24126"],"URL":"https:\/\/doi.org\/10.1002\/mus.24126","archive":["Portico"],"relation":{},"ISSN":["0148-639X","1097-4598"],"issn-type":[{"value":"0148-639X","type":"print"},{"value":"1097-4598","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,4,8]]}}}