{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T22:25:14Z","timestamp":1789597514685,"version":"build-2803163510"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,5,15]],"date-time":"2014-05-15T00:00:00Z","timestamp":1400112000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013053","name":"Hotchkiss Brain Institute","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100013053","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000261","name":"Multiple Sclerosis Society of Canada","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000261","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p><jats:italic>Introduction<\/jats:italic>: Skin\u2010derived precursor cells (SKPs) are neural crest progenitor cells that can attain a Schwann cell\u2013like phenotype through <jats:italic>in vitro<\/jats:italic> techniques (SKP\u2010SCs). We hypothesized that SKP\u2010SCs could produce mature myelin and, in doing so, facilitate the recovery of a focal demyelination injury. <jats:italic>Methods<\/jats:italic>: We unilaterally injected DiI\u2010labeled, green fluorescent protein (GFP)\u2010producing SKP\u2010SCs into the tibial nerves of 10 adult Lewis rats (with contralateral media control), 9 days after bilateral doxorubicin injury (0.38 \u03bcg). Tibial compound motor action potentials (CMAPs) were followed for 57 days. A separate morphometric cohort also included a Schwann cell injection group. <jats:italic>Results<\/jats:italic>: SKP\u2010injected nerves recovered fastest in terms of electrophysiology and morphometry. SKP\u2010SCs formed morphologically mature myelin, accounting for 15.3\u2009\u00b1\u20095.3% of the total myelin in SKP\u2010SC\u2013injected nerves. <jats:italic>Conclusions<\/jats:italic>: SKP\u2010SCs are robustly capable of myelination. They improve the recovery of a focal tibial nerve demyelination model by myelinating a measured percentage of axons. <jats:italic>Muscle Nerve<\/jats:italic> 50:262\u2013272, 2014<\/jats:p>","DOI":"10.1002\/mus.24136","type":"journal-article","created":{"date-parts":[[2013,11,27]],"date-time":"2013-11-27T03:11:12Z","timestamp":1385521872000},"page":"262-272","source":"Crossref","is-referenced-by-count":22,"title":["Skin\u2010derived precursor schwann cell myelination capacity in focal tibial demyelination"],"prefix":"10.1002","volume":"50","author":[{"given":"Joey","family":"Grochmal","sequence":"first","affiliation":[{"name":"Department of Clinical Neuroscience Faculty of Medicine University of Calgary HMRB 110\u2010330 Hospital Drive NW Calgary Alberta T2N4N1 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sundeep","family":"Dhaliwal","sequence":"additional","affiliation":[{"name":"Department of Clinical Neuroscience Faculty of Medicine University of Calgary HMRB 110\u2010330 Hospital Drive NW Calgary Alberta T2N4N1 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter K.","family":"Stys","sequence":"additional","affiliation":[{"name":"Department of Clinical Neuroscience Faculty of Medicine University of Calgary HMRB 110\u2010330 Hospital Drive NW Calgary Alberta T2N4N1 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"van Minnen","sequence":"additional","affiliation":[{"name":"Department of Cell Biology and Anatomy Faculty of Medicine University of Calgary Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajiv","family":"Midha","sequence":"additional","affiliation":[{"name":"Department of Clinical Neuroscience Faculty of Medicine University of Calgary HMRB 110\u2010330 Hospital Drive NW Calgary Alberta T2N4N1 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,5,15]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02740621"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-15-06696.2002"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00939235"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.1997.6693"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1089\/107632704322791808"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1227\/01.NEU.0000335651.93926.2F"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2007-0281"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2004-0134"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2009.05.025"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2009.08.072"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1007-06.2006"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1930-07.2007"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/111.4.901"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1007-06.2006"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.71.9.6641-6649.1997"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2429-08.2008"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.21196"},{"key":"e_1_2_7_19_1","first-page":"281","article-title":"Pharmacokinetics of Adriamycin after intravenous administration in Rat","volume":"4","author":"Nwankwoala R","year":"2009","journal-title":"Res. 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