{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T16:42:46Z","timestamp":1790959366158,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,6,16]],"date-time":"2014-06-16T00:00:00Z","timestamp":1402876800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p><jats:italic>Introduction<\/jats:italic>: Familial amyloid polyneuropathy is a rare condition caused by mutations of the transthyretin gene (<jats:italic>TTR<\/jats:italic>). We assessed the pattern of nerve ultrasound (US) abnormalities in patients with <jats:italic>TTR<\/jats:italic>\u2010related neuropathy. <jats:italic>Methods<\/jats:italic>: Seven patients with <jats:italic>TTR<\/jats:italic>\u2010related neuropathy (TTR\u2010N) and 5 asymptomatic <jats:italic>TTR<\/jats:italic>\u2010mutation carriers (TTR\u2010C) underwent neurological examination, nerve conduction studies, and US evaluation. <jats:italic>Results<\/jats:italic>: Multifocal US abnormalities were identified in 6 of 7 TTR\u2010N patients. A single patient with only a mild sensory polyneuropathy had normal nerves on US evaluation. In the TTR\u2010C, we only detected an enlarged ulnar nerve at the elbow. Interestingly, disease severity correlated with number of nerves affected on US evaluation. <jats:italic>Conclusions<\/jats:italic>: No specific pattern of US abnormalities was identified in this cohort. However, in <jats:italic>TTR<\/jats:italic>\u2010related amyloid neuropathy, US may be a helpful tool in monitoring disease progression, and\/or clinical response to pharmacological treatment. <jats:italic>Muscle Nerve<\/jats:italic> <jats:bold>50<\/jats:bold>: 372\u2013376, 2014<\/jats:p>","DOI":"10.1002\/mus.24168","type":"journal-article","created":{"date-parts":[[2014,1,7]],"date-time":"2014-01-07T09:34:47Z","timestamp":1389087287000},"page":"372-376","source":"Crossref","is-referenced-by-count":43,"title":["Ultrasound evaluation in transthyretin\u2010related amyloid neuropathy"],"prefix":"10.1002","volume":"50","author":[{"given":"Giuseppe","family":"Granata","sequence":"first","affiliation":[{"name":"Institute of Neurology Catholic University of Sacred Heart Largo F. Vito 1 00168 Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Luigetti","sequence":"additional","affiliation":[{"name":"Institute of Neurology Catholic University of Sacred Heart Largo F. Vito 1 00168 Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"Coraci","sequence":"additional","affiliation":[{"name":"Don Gnocchi Foundation Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Del Grande","sequence":"additional","affiliation":[{"name":"Institute of Neurology Catholic University of Sacred Heart Largo F. Vito 1 00168 Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Romano","sequence":"additional","affiliation":[{"name":"Institute of Neurology Catholic University of Sacred Heart Largo F. 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