{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T18:12:37Z","timestamp":1776967957825,"version":"3.51.4"},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,5,14]],"date-time":"2014-05-14T00:00:00Z","timestamp":1400025600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p><jats:italic>Introduction<\/jats:italic>: To elucidate the mechanism of functional recovery after gradual nerve\u2010stretch injury, we used rats in which the femur length was increased by 15 mm at 1.5 mm\/day. <jats:italic>Methods<\/jats:italic>: We performed electrophysiology, mRNA analysis of tetrodotoxin\u2010resistant voltage\u2010gated sodium channels (TTX\u2010R VGSCs) in dorsal root ganglia, and histology of unmyelinated sciatic nerve fibers and examined pain thresholds at 1, 10, 20, and 30 days after cessation of lengthening. <jats:italic>Results<\/jats:italic>: Electrophysiology revealed conduction block after cessation that recovered after 30 days. TTX\u2010R VGSC levels decreased immediately after cessation but were restored after 10 (Nav1.9) or 20 (Nav1.8) days. Histology revealed that injured unmyelinated nerve fibers regenerate 30 days after cessation. Pain threshold decreased gradually during lengthening but had not recovered to the control group level after 30 days. <jats:italic>Conclusions<\/jats:italic>: Early restoration of TTX\u2010R VGSC mRNA in dorsal root ganglia preceded functional recovery of stretched nerves before regeneration of injured unmyelinated nerve fibers. <jats:italic>Muscle Nerve<\/jats:italic> <jats:bold>50<\/jats:bold>: 425\u2013430, 2014<\/jats:p>","DOI":"10.1002\/mus.24172","type":"journal-article","created":{"date-parts":[[2014,1,7]],"date-time":"2014-01-07T17:59:40Z","timestamp":1389117580000},"page":"425-430","source":"Crossref","is-referenced-by-count":7,"title":["Role of sodium channels in recovery of sciatic nerve\u2010stretch injury in rats"],"prefix":"10.1002","volume":"50","author":[{"given":"Shinji","family":"Hirofuji","sequence":"first","affiliation":[{"name":"Department of Orthopedic Surgery Osaka Medical College 2\u20107, Daigaku\u2010machi, Takatsuki Osaka 569\u20108686 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Yokota","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Osaka Medical College 2\u20107, Daigaku\u2010machi, Takatsuki Osaka 569\u20108686 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsunori","family":"Ohno","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Osaka Medical College 2\u20107, Daigaku\u2010machi, Takatsuki Osaka 569\u20108686 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsuo","family":"Kinoshita","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Osaka Medical College 2\u20107, Daigaku\u2010machi, Takatsuki Osaka 569\u20108686 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masashi","family":"Neo","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Osaka Medical College 2\u20107, Daigaku\u2010machi, Takatsuki Osaka 569\u20108686 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,5,14]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-200308000-00011"},{"key":"e_1_2_6_3_1","first-page":"517","article-title":"Voltage\u2010gated sodium channels and the molecular pathogenesis of pain: a review","volume":"37","author":"Waxman SG","year":"2000","journal-title":"J Rehabil Res Dev"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2006.10.009"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1254\/jphs.CRJ06012X"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-3806(92)90012-L"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1993.sp019706"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00410194"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.21024"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(92)90041-9"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(00)00332-8"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-19-07279.2000"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0270(94)90144-9"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pa.20.040180.002301"},{"key":"e_1_2_6_15_1","first-page":"29","article-title":"Distribution of sodium channel during nerve elongation and subsequent recovery process","volume":"16","author":"Ichimura H","year":"2005","journal-title":"Peripheral Nerve"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(92)91687-A"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.12-06-02104.1992"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(94)11227-A"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.17-10-03503.1997"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.25.14950"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0736-0266(02)00100-6"}],"container-title":["Muscle &amp; 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