{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T01:30:14Z","timestamp":1792459814828,"version":"4.5.0"},"reference-count":17,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,8,5]],"date-time":"2014-08-05T00:00:00Z","timestamp":1407196800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p><jats:italic>Introduction<\/jats:italic>: We performed a population\u2010based study to assess amyotrophic lateral sclerosis (ALS) survival after noninvasive ventilation (NIV), invasive ventilation (IV), and enteral nutrition (EN). <jats:italic>Methods<\/jats:italic>: We included patients diagnosed from 2000 to 2009 in Modena, where a prospective registry and a Motor Neuron Diseases Centre have been active since 2000. <jats:italic>Results<\/jats:italic>: Of the 193 incident cases, 47.7% received NIV, 24.3% received tracheostomy, and 49.2% received EN. A total of 10.4% of the patients refused NIV, 31.6% refused IV, and 8.7% refused EN. The median survival times after NIV, IV, and EN were 15, 19, and 9 months, respectively. Of the tracheostomized patients, 79.7% were discharged from the hospital; 73.0% were discharged to home. The median survival times for tracheostomized patients who were cared for at home and in nursing homes were 43 and 2 months, respectively. The multivariate analysis demonstrated that the place of discharge was the only independent prognostic factor after IV (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01). <jats:italic>Conclusions<\/jats:italic>: Service organizations may promote adherence to NIV, IV, EN, and influence postprocedure survival. These data may be useful in defining health plans regarding advanced ALS care and in patient counseling. <jats:italic>Muscle Nerve<\/jats:italic> 50: 508\u2013516, 2014<\/jats:p>","DOI":"10.1002\/mus.24187","type":"journal-article","created":{"date-parts":[[2014,1,22]],"date-time":"2014-01-22T11:53:39Z","timestamp":1390391619000},"page":"508-516","source":"Crossref","is-referenced-by-count":25,"title":["Noninvasive and invasive ventilation and enteral nutrition for ALS in Italy"],"prefix":"10.1002","volume":"50","author":[{"given":"Nicola","family":"Fini","sequence":"first","affiliation":[{"name":"Department of Neuroscience S. Agostino\u2010Estense Hospital and University of Modena and Reggio Emilia Via P. Giardini 1355 41126 Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleni","family":"Georgoulopoulou","sequence":"additional","affiliation":[{"name":"Department of Neuroscience S. Agostino\u2010Estense Hospital and University of Modena and Reggio Emilia Via P. Giardini 1355 41126 Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Vinceti","sequence":"additional","affiliation":[{"name":"Department of Diagnostic, Clinical and Public Health Medicine University of Modena and Reggio Emilia Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Monelli","sequence":"additional","affiliation":[{"name":"Section of Respiratory Diseases, Department of Oncology, Hematology, and Respiratory Diseases University of Modena and Reggio Emilia Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Pinelli","sequence":"additional","affiliation":[{"name":"Department of Emergency and Critical Care Medicine S. Agostino\u2010Estense Hospital Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Vacondio","sequence":"additional","affiliation":[{"name":"Department of Primary Care Health District Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Giovannini","sequence":"additional","affiliation":[{"name":"Department of Respiratory Diseases St Maria Bianca Hospital Mirandola Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rossano","family":"Dallari","sequence":"additional","affiliation":[{"name":"Department of Respiratory Diseases Sassuolo Civil Hospital Sassuolo Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Marudi","sequence":"additional","affiliation":[{"name":"Department of Emergency and Critical Care Medicine S. Agostino\u2010Estense Hospital Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Mandrioli","sequence":"additional","affiliation":[{"name":"Department of Neuroscience S. Agostino\u2010Estense Hospital and University of Modena and Reggio Emilia Via P. Giardini 1355 41126 Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,8,5]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2011.03501.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(05)70326-4"},{"key":"e_1_2_7_4_1","first-page":"CD004427","article-title":"Mechanical ventilation for amyotrophic lateral sclerosis\/motor neuron disease","volume":"3","author":"Radunovic A","year":"2013","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2011-300472"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2009.175984"},{"key":"e_1_2_7_7_1","first-page":"1218e26","article-title":"Practice parameters update: the care of the patient with amyotrophic lateral sclerosis: drug, nutritional, and respiratory therapies (an evidence\u2010based review)","volume":"73","author":"Miller RG","year":"2009","journal-title":"Neurology"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.3109\/17482968.2011.593037"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.3109\/21678421.2013.763281"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.3109\/17482968.2012.726226"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2008.11.013"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2012.08.011"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2010.06.003"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2006.10.007"},{"issue":"1","key":"e_1_2_7_15_1","first-page":"S134","article-title":"Quality of life for ventilator\u2010dependent ALS patients and their caregivers","volume":"160","author":"Gelinas DF","year":"2008","journal-title":"J Neurol Sci"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.23282"},{"key":"e_1_2_7_17_1","first-page":"249","article-title":"Patients with amyotrophic lateral sclerosis receiving long\u2010term mechanical ventilation","volume":"110","author":"Moss AH","year":"1996","journal-title":"Advance care planning and outcomes. 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