{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T19:28:59Z","timestamp":1790710139400,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,8,30]],"date-time":"2014-08-30T00:00:00Z","timestamp":1409356800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Introduction<\/jats:italic>\n                    : The aim of this study was to determine factors affecting health\u2010related quality of life (HRQOL) and to propose appropriate treatment targets for patients with myasthenia gravis (MG).\n                    <jats:italic>Methods<\/jats:italic>\n                    : We evaluated 640 consecutive patients with MG seen at 11 neurological centers. Two\u2010year follow\u2010up data were obtained for 282 patients. Correlations between detailed clinical factors and the Japanese version of the 15\u2010item MG\u2010specific QOL scale score were analyzed.\n                    <jats:italic>Results<\/jats:italic>\n                    : In a cross\u2010sectional analysis of 640 MG patients, multivariate regression revealed that disease severity, as evaluated by the MG Composite (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.0001), total dose of oral prednisolone during the last year (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.002), and Cushingoid appearance index (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.0004), showed significant negative effects on HRQOL, but the quantitative MG score and current prednisolone dose did not.\n                    <jats:italic>Conclusions<\/jats:italic>\n                    : Achieving minimal manifestations (MM) status or better with prednisolone \u22645 mg\/day was found to exert a major positive impact on HRQOL in both the cross\u2010sectional and 2\u2010year follow\u2010up patient samples and can be recommended as a treatment target.\n                    <jats:italic>Muscle Nerve<\/jats:italic>\n                    50: 493\u2013500, 2014\n                  <\/jats:p>","DOI":"10.1002\/mus.24213","type":"journal-article","created":{"date-parts":[[2014,2,18]],"date-time":"2014-02-18T07:41:11Z","timestamp":1392709271000},"page":"493-500","source":"Crossref","is-referenced-by-count":94,"title":["Health\u2010related quality\u2010of\u2010life and treatment targets in myasthenia gravis"],"prefix":"10.1002","volume":"50","author":[{"given":"Kimiaki","family":"Utsugisawa","sequence":"first","affiliation":[{"name":"Department of Neurology Hanamaki General Hospital 4\u201328 Kajoh\u2010chou Hanamaki 025\u20130075 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeaki","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Neurology Keio University School of Medicine Shinjuku\u2010ku Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuriko","family":"Nagane","sequence":"additional","affiliation":[{"name":"Department of Neurology Hanamaki General Hospital 4\u201328 Kajoh\u2010chou Hanamaki 025\u20130075 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayuki","family":"Masuda","sequence":"additional","affiliation":[{"name":"Department of Neurology Tokyo Medical University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1612-1440","authenticated-orcid":false,"given":"Hiroyuki","family":"Murai","sequence":"additional","affiliation":[{"name":"Department of Neurology Iizuka Hospital Iizuka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomihiro","family":"Imai","sequence":"additional","affiliation":[{"name":"Department of Neurology Sapporo Medical University Hospital Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emiko","family":"Tsuda","sequence":"additional","affiliation":[{"name":"Department of Neurology Sapporo Medical University Hospital Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shingo","family":"Konno","sequence":"additional","affiliation":[{"name":"Department of Neurology Toho University Medical Center Oh\u2010hashi Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunya","family":"Nakane","sequence":"additional","affiliation":[{"name":"Department of Neurology Nagasaki Kawatana Medical Center Higashi\u2010Sonogi\u2010Gun 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Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,8,30]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1586\/14737175.9.3.351"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.3109\/08916930903518107"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410150316"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.23398"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.20950"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.21053"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.1034"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.21713"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.55.1.16"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.21053"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.21609"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.21883"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.21185"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181dc1b1e"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2012-304057"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2011-000313"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1159\/000319172"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1159\/000322497"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1405.040"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2011.03.004"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.74.8.1105"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000176067.32186.a3"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.23260"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2011-301449"}],"container-title":["Muscle 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