{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T00:14:05Z","timestamp":1789690445416,"version":"4.0.1"},"reference-count":35,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,9,29]],"date-time":"2014-09-29T00:00:00Z","timestamp":1411948800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100006314","name":"Biogen Idec","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100006314","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p><jats:italic>Introduction<\/jats:italic>: Mitochondrial dysfunction in the motor neuron has been suspected in amyotrophic lateral sclerosis (ALS). If mitochondrial abnormalities are also found in skeletal muscle, assessing skeletal muscle could serve as an important biomarker of disease progression. <jats:italic>Methods<\/jats:italic>: Using <jats:sup>31<\/jats:sup>P magnetic resonance (<jats:sup>31<\/jats:sup>P\u2010MRS) and near infrared (NIRS) spectroscopy, we compared the absolute values and reproducibility of skeletal muscle oxidative capacity in people with ALS (<jats:italic>n<\/jats:italic>\u2009=\u20096) and healthy adults (young, <jats:italic>n<\/jats:italic>\u2009=\u20097 and age\u2010matched, <jats:italic>n<\/jats:italic>\u2009=\u20094). <jats:italic>Results<\/jats:italic>: ALS patients had slower time constants for phosphocreatine (PCr) and muscle oxygen consumption (mVO<jats:sub>2<\/jats:sub>) compared with young, but not age\u2010matched controls. The coefficient of variation for the time constant was 10% (SD\u2009=\u20092.8%) and 17% (SD\u2009=\u20096.2%) for PCr and mVO<jats:sub>2<\/jats:sub>, respectively. <jats:italic>Conclusions<\/jats:italic>: People with ALS had, on average, a small but not statistically significant, impairment in skeletal muscle mitochondrial function measured by both <jats:sup>31<\/jats:sup>P\u2010MRS and NIRS. Both methods demonstrated good reproducibility. <jats:italic>Muscle Nerve<\/jats:italic> <jats:bold>50<\/jats:bold>: 767\u2013774, 2014<\/jats:p>","DOI":"10.1002\/mus.24223","type":"journal-article","created":{"date-parts":[[2014,2,24]],"date-time":"2014-02-24T18:23:49Z","timestamp":1393266229000},"page":"767-774","source":"Crossref","is-referenced-by-count":32,"title":["Skeletal muscle oxidative capacity in amyotrophic lateral sclerosis"],"prefix":"10.1002","volume":"50","author":[{"given":"Terence E.","family":"Ryan","sequence":"first","affiliation":[{"name":"Department of Kinesiology University of Georgia Athens Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa L.","family":"Erickson","sequence":"additional","affiliation":[{"name":"Department of Kinesiology University of Georgia Athens Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajay","family":"Verma","sequence":"additional","affiliation":[{"name":"Experimental Medicine, Biogen Idec Cambridge Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Chavez","sequence":"additional","affiliation":[{"name":"Experimental Medicine, Biogen Idec Cambridge Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael H.","family":"Rivner","sequence":"additional","affiliation":[{"name":"Department of Neurology Georgia Regents University Augusta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin K.","family":"Mccully","sequence":"additional","affiliation":[{"name":"Department of Kinesiology University of Georgia Athens Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,9,29]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200105313442207"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1993.tb07478.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/123.7.1339"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awf167"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-0186(01)00125-5"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.20566"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2005.07.020"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.112.192138"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1988.254.4.C548"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/17482960600765065"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.45.4.733"},{"key":"e_1_2_7_13_1","first-page":"123","article-title":"Near\u2010infrared spectroscopy: what can it tell us about oxygen saturation in skeletal muscle?","volume":"28","author":"McCully KK","year":"2000","journal-title":"Exerc Sport Sci Rev"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00319.2012"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/1476-5918-3-2"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1098\/rsta.2011.0298"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01043.2012"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1080\/146608200300079536"},{"key":"e_1_2_7_19_1","unstructured":"Medical Research Council.Aids to the examination of the peripheral nervous system Memorandum No. 45. 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