{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T22:46:58Z","timestamp":1782859618954,"version":"3.54.5"},"reference-count":52,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,8,12]],"date-time":"2014-08-12T00:00:00Z","timestamp":1407801600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>It is unknown how often cardiac arrhythmias occur in hypokalemic periodic paralysis (HypoPP) and if they are caused by hypokalemia alone or other factors. This systematic review shows that cardiac arrhythmias were reported in 27 HypoPP patients. Cases were confirmed genetically (13 with an R528H mutation in <jats:italic>CACNA1S<\/jats:italic>, 1 an R669H mutation in <jats:italic>SCN4A<\/jats:italic>) or had a convincing clinical diagnosis of HypoPP (13 genetically undetermined) if reported prior to the availability of genetic testing. Arrhythmias occurred during severe hypokalemia (11 patients), between attacks at normokalemia (4 patients), were treatment\u2010dependent (2 patients), or unspecified (10 patients). Nine patients died from arrhythmia. Convincing evidence for a pro\u2010arrhythmogenic factor other than hypokalemia is still lacking. The role of cardiac expression of defective skeletal muscle channels in the heart of HypoPP patients remains unclear. Clinicians should be aware of and prevent treatment\u2010induced cardiac arrhythmia in HypoPP. <jats:italic>Muscle Nerve<\/jats:italic> <jats:bold>50<\/jats:bold>: 327\u2013332, 2014<\/jats:p>","DOI":"10.1002\/mus.24225","type":"journal-article","created":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T22:03:55Z","timestamp":1406930635000},"page":"327-332","source":"Crossref","is-referenced-by-count":14,"title":["Cardiac arrhythmias in hypokalemic periodic paralysis: Hypokalemia as only cause?"],"prefix":"10.1002","volume":"50","author":[{"given":"Bas C.","family":"Stunnenberg","sequence":"first","affiliation":[{"name":"Donders Institute for Brain, Cognition and Behaviour, Department of Neurology Radboud University Nijmegen Medical Centre Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaap","family":"Deinum","sequence":"additional","affiliation":[{"name":"Department of Medicine Radboud University Nijmegen Medical Centre Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thera P.","family":"Links","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, University of Groningen University Medical Center Groningen Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur A.","family":"Wilde","sequence":"additional","affiliation":[{"name":"Department of Cardiology Amsterdam Medical Centre, Amsterdam Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hessel","family":"Franssen","sequence":"additional","affiliation":[{"name":"Department of Neurology and Rudolf Magnus Institute of Neurosciences University Medical Center Utrecht Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gea","family":"Drost","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Groningen University Medical Center Groningen P.O. 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