{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T04:25:52Z","timestamp":1758860752085,"version":"3.37.3"},"reference-count":52,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,9,29]],"date-time":"2014-09-29T00:00:00Z","timestamp":1411948800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["Matthews Rehab"],"award-info":[{"award-number":["Matthews Rehab"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p><jats:italic>Introduction<\/jats:italic>: We examined the possibility that tetanus toxin can prevent muscle atrophy associated with limb immobility in rats. <jats:italic>Methods<\/jats:italic>: While the knee and ankle joints were immobilized unilaterally, the tibialis anterior (TA) muscle on the immobilized side was injected with 1 \u03bcl saline or with 1 ng tetanus toxin. After 2 weeks, TA wet weights, contractile forces, and myofiber sizes from the immobilized sides were compared with those from body weight\u2013matched normal animals. <jats:italic>Results<\/jats:italic>: Saline group wet weights decreased and produced less absolute twitch and tetanic force and normalized tetanic force compared with the toxin or normal groups. Cross\u2010sectional areas of saline group type I, IIa, and IId myofibers, and the masses of saline group IIa, IId, IIb, and toxin group IIb myofibers, were smaller compared with the normal group. <jats:italic>Conclusions<\/jats:italic>: Tetanus toxin prevented common signs of muscle atrophy and may become a useful adjunct to current rehabilitation strategies. <jats:italic>Muscle Nerve<\/jats:italic> <jats:bold>50<\/jats:bold>: 759\u2013766, 2014<\/jats:p>","DOI":"10.1002\/mus.24231","type":"journal-article","created":{"date-parts":[[2014,3,3]],"date-time":"2014-03-03T15:28:53Z","timestamp":1393860533000},"page":"759-766","source":"Crossref","is-referenced-by-count":2,"title":["Tetanus toxin preserves skeletal muscle contractile force and size during limb immobilization"],"prefix":"10.1002","volume":"50","author":[{"given":"Christopher C.","family":"Matthews","sequence":"first","affiliation":[{"name":"Research Service, VA Maryland Health Care System 10 North Greene Street Baltimore 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