{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T19:07:10Z","timestamp":1790708830828,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,10,30]],"date-time":"2014-10-30T00:00:00Z","timestamp":1414627200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p><jats:italic>Introduction<\/jats:italic>: Protease\u2010activated receptors (PARs) may play a role in skeletal muscle development. We compared the contractile properties of slow\u2010twitch soleus muscles and fast\u2010twitch extensor digitorum longus (EDL) muscles from PAR\u20101 null and littermate control mice. <jats:italic>Methods<\/jats:italic>: Contractile function was measured using a force transducer system. Fiber type proportions were determined using immunohistochemistry. <jats:italic>Results<\/jats:italic>: Soleus muscles from PAR\u20101 null mice exhibited longer contraction times, a leftward shift in the force\u2013stimulation frequency relationship, and decreased fatiguability compared with controls. PAR\u20101 null soleus muscles also had increased type 1 and decreased type IIb\/x fiber numbers compared with controls. In PAR\u20101 null EDL muscles, no differences were found, except for a slower rate of fatigue compared with controls. <jats:italic>Conclusions<\/jats:italic>: The absence of PAR\u20101 results in a slower skeletal muscle contractile phenotype, likely due to an increase in type I and a decrease in type IIb\/x fiber numbers. <jats:italic>Muscle Nerve<\/jats:italic> 50: 991\u2013998, 2014<\/jats:p>","DOI":"10.1002\/mus.24256","type":"journal-article","created":{"date-parts":[[2014,4,1]],"date-time":"2014-04-01T10:40:17Z","timestamp":1396348817000},"page":"991-998","source":"Crossref","is-referenced-by-count":4,"title":["Contractile properties of slow and fast skeletal muscles from protease activated receptor\u20101 null mice"],"prefix":"10.1002","volume":"50","author":[{"given":"Paran K.","family":"Sitparan","sequence":"first","affiliation":[{"name":"School of Anatomy, Physiology and Human Biology, M311, The University of Western Australia Crawley WA 6009 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles N.","family":"Pagel","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Science The University of Melbourne Parkville VIC 3010 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gavin J.","family":"Pinniger","sequence":"additional","affiliation":[{"name":"School of Anatomy, Physiology and Human Biology, M311, The University of Western Australia Crawley WA 6009 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.J.","family":"Yoo","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Science The University of Melbourne Parkville VIC 3010 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleanor J.","family":"Mackie","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Science The University of Melbourne Parkville VIC 3010 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