{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T22:01:37Z","timestamp":1773525697944,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,11,19]],"date-time":"2014-11-19T00:00:00Z","timestamp":1416355200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p><jats:italic>Introduction<\/jats:italic>: After nerve injury, excessive calcium impedes nerve regeneration. We previously showed that calcitonin improved nerve regeneration in crush injury. We aimed to validate the direct effect of calcitonin on transected and repaired nerve. <jats:italic>Methods<\/jats:italic>: Two rat groups (<jats:italic>n<\/jats:italic>\u2009=\u20098) underwent sciatic nerve transection followed by direct repair. In the calcitonin group, a calcitonin\u2010filled mini\u2010osmotic pump was implanted subcutaneously, with a catheter parallel to the repaired nerve. The control group underwent repair only, without a pump. Evaluation and comparison between the groups included: (1) compound muscle action potential recording of the extensor digitorum longus (EDL) muscle; (2) tetanic muscle force test of EDL; (3) nerve calcium concentration; and (4) nerve fiber count and calcified spot count. <jats:italic>Results<\/jats:italic>: The calcitonin pump group showed superior recovery. <jats:italic>Conclusions<\/jats:italic>: Calcitonin affects injured and repaired peripheral nerve directly. The calcitonin\u2010filled mini\u2010osmotic pump improved nerve functional recovery by accelerating calcium absorption from the repaired nerve. This finding has potential clinical applications. Muscle Nerve <jats:bold>51<\/jats:bold>: 229\u2013234, 2015<\/jats:p>","DOI":"10.1002\/mus.24281","type":"journal-article","created":{"date-parts":[[2014,5,9]],"date-time":"2014-05-09T08:58:59Z","timestamp":1399625939000},"page":"229-234","source":"Crossref","is-referenced-by-count":2,"title":["Calcitonin pump improves nerve regeneration after transection injury and repair"],"prefix":"10.1002","volume":"51","author":[{"given":"Ji\u2010Geng","family":"Yan","sequence":"first","affiliation":[{"name":"Department of Plastic Surgery Medical College of Wisconsin 8700 Watertown Plank Road Milwaukee Wisconsin 53226 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Logiudice","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery Medical College of Wisconsin 8700 Watertown Plank Road Milwaukee Wisconsin 53226 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Davis","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery Medical College of Wisconsin 8700 Watertown Plank Road Milwaukee Wisconsin 53226 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin\u2010Ling","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery Medical College of Wisconsin 8700 Watertown Plank Road Milwaukee Wisconsin 53226 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Agresti","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery Medical College of Wisconsin 8700 Watertown Plank Road Milwaukee Wisconsin 53226 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Sanger","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery Medical College of Wisconsin 8700 Watertown Plank Road Milwaukee Wisconsin 53226 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hani S.","family":"Matloub","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery Medical College of Wisconsin 8700 Watertown Plank Road Milwaukee Wisconsin 53226 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Havlik","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery Medical College of Wisconsin 8700 Watertown Plank Road Milwaukee Wisconsin 53226 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,11,19]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/neu.480220702"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(91)90243-S"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(88)90195-6"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.87.11.4212"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(94)90272-0"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/micr.20709"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2002-36503"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11062-012-9297-6"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1006\/taap.1997.8106"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(01)00557-8"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(84)90969-7"},{"key":"e_1_2_6_13_1","first-page":"217","article-title":"Role of extracellular calcium and magnesium in ischemic neuronal injury in vitro","volume":"39","author":"Goldberg MP","year":"1989","journal-title":"Neurology"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2009.05853.x"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.21859"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1089\/cns.1985.2.231"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.1989.6.261"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.10-11-03564.1990"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.10.4.437"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2013.04.013"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.3.13.2572500"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.12.5705"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(98)00731-3"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/1744-8069-8-42"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2013.01.002"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1177\/0023677212473712"}],"container-title":["Muscle &amp; 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