{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:02:08Z","timestamp":1790035328907,"version":"4.0.1"},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,11,21]],"date-time":"2014-11-21T00:00:00Z","timestamp":1416528000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K23 NS066789"],"award-info":[{"award-number":["K23 NS066789"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p><jats:italic>Introduction<\/jats:italic>: Distal symmetric polyneuropathy (DSP) is common in HIV and is associated with autonomic impairment. However tools to measure HIV\u2010DSP do not include autonomic indices. We sought to optimize the Total Neuropathy Score (TNS) and the Composite Autonomic Severity Score (CASS) for use in HIV. <jats:italic>Methods<\/jats:italic>: HIV\u2010infected adults (<jats:italic>n<\/jats:italic>\u2009=\u2009102) underwent neurologic examination, quantitative sensory testing (QST), nerve conduction studies, and autonomic testing. Modifications of the TNS and CASS were assessed for validity based on correlation with the original measure and internal consistency. <jats:italic>Results<\/jats:italic>: The TNS version commonly used in HIV\u2010DSP is valid, but it is improved by elimination of QST and addition of autonomic indices. A modified version of the CASS (M\u2010CASS) which was designed for sensitivity to milder impairment was also valid. <jats:italic>Conclusions<\/jats:italic>: A modified TNS that excludes QST and includes autonomic indices is optimal for HIV\u2010DSP. The M\u2010CASS is a valid measure of autonomic impairment in HIV. <jats:italic>Muscle Nerve<\/jats:italic> <jats:bold>51<\/jats:bold>: 56\u201364, 2015<\/jats:p>","DOI":"10.1002\/mus.24282","type":"journal-article","created":{"date-parts":[[2014,5,9]],"date-time":"2014-05-09T09:03:36Z","timestamp":1399626216000},"page":"56-64","source":"Crossref","is-referenced-by-count":10,"title":["Optimizing measures of HIV\u2010associated neuropathy"],"prefix":"10.1002","volume":"51","author":[{"given":"Jessica","family":"Robinson\u2010Papp","sequence":"first","affiliation":[{"name":"Icahn School of Medicine at Mount Sinai Department of Neurology Box 1052, One Gustave L. Levy Place New York New York 10029 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandeep","family":"Sharma","sequence":"additional","affiliation":[{"name":"Icahn School of Medicine at Mount Sinai Department of Neurology Box 1052, One Gustave L. Levy Place New York New York 10029 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neetu","family":"Dhadwal","sequence":"additional","affiliation":[{"name":"Icahn School of Medicine at Mount Sinai Department of Neurology Box 1052, One Gustave L. Levy Place New York New York 10029 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M.","family":"Simpson","sequence":"additional","affiliation":[{"name":"Icahn School of Medicine at Mount Sinai Department of Neurology Box 1052, One Gustave L. Levy Place New York New York 10029 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Morgello","sequence":"additional","affiliation":[{"name":"Icahn School of Medicine at Mount Sinai Department of Neurology Box 1052, One Gustave L. Levy Place New York New York 10029 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,11,21]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.61.4.546"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2010.76"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13365-013-0160-3"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.53.8.1660"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1085-9489.2006.00078.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000218303.48113.5d"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00042560-199508000-00008"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-6196(12)60631-4"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1089\/apc.2013.0188"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1998.85.3.817"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/14.11.1519"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.27.7.1177"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182120147"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.3791\/2502"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.64.3.381"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.23231"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2010.08.045"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.27.12.2942"}],"container-title":["Muscle &amp; Nerve"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmus.24282","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmus.24282","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.24282","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T00:18:08Z","timestamp":1696378688000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mus.24282"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11,21]]},"references-count":18,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,1]]}},"alternative-id":["10.1002\/mus.24282"],"URL":"https:\/\/doi.org\/10.1002\/mus.24282","archive":["Portico"],"relation":{},"ISSN":["0148-639X","1097-4598"],"issn-type":[{"value":"0148-639X","type":"print"},{"value":"1097-4598","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,11,21]]}}}