{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T16:14:30Z","timestamp":1773418470348,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,11,19]],"date-time":"2014-11-19T00:00:00Z","timestamp":1416355200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000863","name":"Ellison Medical Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000863","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p><jats:italic>Introduction<\/jats:italic>: Mutations in the inner nuclear envelope protein emerin cause Emery\u2010Dreifuss muscular dystrophy (EDMD), which is characterized by progressive skeletal muscle wasting, cardiac conduction defects, and tendon contractures. We previously showed that emerin binds directly to the transcription regulator Lmo7 and attenuates its activity to regulate the proper temporal expression of important myogenic differentiation genes. <jats:italic>Methods<\/jats:italic>: The skeletal muscle and cardiac phenotypes were analyzed in a newly generated Lmo7\u2010null mouse using histological analysis, echocardiography, and various neuromuscular tests to determine if Lmo7 was important for skeletal muscle and cardiac function. <jats:italic>Results<\/jats:italic>: Lmo7\u2010null mice had growth retardation, decreased fiber size, and impaired skeletal muscle and cardiac function. Lmo7\u2010null mice also had lower levels of phosphorylated retinoblastoma (Rb), extracellular signal\u2010regulated kinase, and c\u2010Jun N\u2010terminal kinase, which is consistent with altered Rb and mitogen\u2010activated protein kinase signaling. <jats:italic>Conclusions<\/jats:italic>: These findings demonstrate that loss of Lmo7 in mice causes myopathic phenotypes similar to those seen in other EDMD mouse models. Muscle Nerve <jats:bold>51<\/jats:bold>: 222\u2013228, 2015<\/jats:p>","DOI":"10.1002\/mus.24286","type":"journal-article","created":{"date-parts":[[2014,5,13]],"date-time":"2014-05-13T16:52:02Z","timestamp":1399999922000},"page":"222-228","source":"Crossref","is-referenced-by-count":22,"title":["LMO7\u2010null mice exhibit phenotypes consistent with emery\u2010dreifuss muscular dystrophy"],"prefix":"10.1002","volume":"51","author":[{"given":"Aaron","family":"Mull","sequence":"first","affiliation":[{"name":"Department of Medicine Section of Cardiology, The University of Chicago Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gene","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Medicine Section of Cardiology, The University of Chicago Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James M.","family":"Holaska","sequence":"additional","affiliation":[{"name":"Department of Medicine Section of Cardiology, The University of Chicago Chicago Illinois USA"},{"name":"Department of Pharmaceutical Sciences University of the Sciences 600 S 43rd Street, MCN\u2010108 Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,11,19]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.4161\/nucl.25751"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.108.172197"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-007-0025-3"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.019042"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddl423"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi602636m"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddi479"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awl023"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.080259"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2336103100"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddg140"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddn343"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s003350010149"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI29042"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddm137"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M801379200"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-4652(200101)186:1<104::AID-JCP1015>3.0.CO;2-0"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2008.10.012"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.109.205724"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.109.212001"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.970673"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2010.04.001"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.147.5.913"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000149763.15180.00"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddi017"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddl170"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature01631"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2010.08.013"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddn386"}],"container-title":["Muscle &amp; 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