{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:45:06Z","timestamp":1787168706513,"version":"build-2736575974"},"reference-count":50,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,11,19]],"date-time":"2014-11-19T00:00:00Z","timestamp":1416355200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"NIHR Respiratory Biomedical Research Unit at the Royal Brompton & Harefield NHS Foundation Trust and Imperial College"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Introduction<\/jats:italic>\n                    : Chronic obstructive pulmonary disease (COPD) is associated with metabolic abnormalities in muscles of the lower limbs, but it is not known whether these abnormalities are generalized or limited to specific muscle groups, nor is there an easy way of predicting their presence.\n                    <jats:italic>Methods<\/jats:italic>\n                    : Metabolism in the quadriceps and biceps of 14 COPD patients and controls was assessed during sustained contraction using 31\u2010phosphorus magnetic resonance spectroscopy (\n                    <jats:sup>31<\/jats:sup>\n                    P MRS). T1 MRI was used to measure quadriceps intermuscular adipose tissue (IMAT).\n                    <jats:italic>Results<\/jats:italic>\n                    : COPD patients had prolonged quadriceps phosphocreatine time (patients: 38.8\u2009\u00b1 12.7 s; controls: 25.2\u2009\u00b1\u200910.6 s;\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.006) and a lower pH (patents: 6.88\u2009\u00b1\u20090.1; controls: 6.99\u2009\u00b1\u20090.06;\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.002). Biceps measures were not significantly different. IMAT was associated with a nadir pH &lt;7.0 (area under the curve\u2009=\u20090.84).\n                    <jats:italic>Conclusions<\/jats:italic>\n                    : Anaerobic metabolism during contraction was characteristic of quadriceps, but not biceps, muscles of patients with COPD and was associated with increased IMAT. Because IMAT can be assessed quickly by conventional MRI, it may be a useful approach for identifying patients with abnormal muscle bioenergetics. Muscle Nerve\n                    <jats:bold>51<\/jats:bold>\n                    : 214\u2013221, 2015\n                  <\/jats:p>","DOI":"10.1002\/mus.24289","type":"journal-article","created":{"date-parts":[[2014,5,16]],"date-time":"2014-05-16T06:15:44Z","timestamp":1400220944000},"page":"214-221","source":"Crossref","is-referenced-by-count":23,"title":["Bioenergetics and intermuscular fat in chronic obstructive pulmonary disease\u2010associated quadriceps weakness"],"prefix":"10.1002","volume":"51","author":[{"given":"Gregory Samuel","family":"Shields","sequence":"first","affiliation":[{"name":"Clinical Imaging Centre, GlaxoSmithKline Research and Development, Hammersmith Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graziele S.","family":"Coissi","sequence":"additional","affiliation":[{"name":"NIHR Respiratory Biomedical Research Unit, Royal Brompton and Harefield NHS Foundation Trust and National Heart &amp; Lung Institute, Imperial College London London SW3 6NP UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pilar","family":"Jimenez\u2010Royo","sequence":"additional","affiliation":[{"name":"Global Imaging Unit, GlaxoSmithKline Research and Development Stevenage UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulio","family":"Gambarota","sequence":"additional","affiliation":[{"name":"Clinical Imaging Centre, GlaxoSmithKline Research and Development, Hammersmith Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahul","family":"Dimber","sequence":"additional","affiliation":[{"name":"Clinical Imaging Centre, GlaxoSmithKline Research and Development, Hammersmith Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas S.","family":"Hopkinson","sequence":"additional","affiliation":[{"name":"NIHR Respiratory Biomedical Research Unit, Royal Brompton and Harefield NHS Foundation Trust and National Heart &amp; 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