{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T17:44:52Z","timestamp":1760204692883},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,8,30]],"date-time":"2014-08-30T00:00:00Z","timestamp":1409356800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p><jats:italic>Introduction<\/jats:italic>: We tested the feasibility of using neuromuscular ultrasound for non\u2010invasive real\u2010time assessment of diaphragmatic structure and function in a canine model of X\u2010linked myotubular myopathy (XLMTM). <jats:italic>Methods<\/jats:italic>: Ultrasound images in 3 dogs [wild\u2010type (WT), <jats:italic>n<\/jats:italic>\u2009=\u20091; XLMTM untreated, <jats:italic>n<\/jats:italic>\u2009=\u20091; XLMTM post\u2013AAV8\u2010mediated MTM1 gene replacement, <jats:italic>n<\/jats:italic>\u2009=\u20091] were analyzed for diaphragm thickness, change in thickness with respiration, muscle echogenicity, and diaphragm excursion amplitude during spontaneous breathing. <jats:italic>Results<\/jats:italic>: Quantitative parameters of diaphragm structure were different among the animals. WT diaphragm was thicker and less echogenic than the XLMTM control, whereas the diaphragm measurements of the MTM1\u2010treated XLMTM dog were comparable to those of the WT dog. <jats:italic>Conclusions<\/jats:italic>: This pilot study demonstrates the feasibility of using ultrasound for quantitative assessment of the diaphragm in a canine model. In the future, ultrasonography may replace invasive measures of diaphragm function in canine models and in humans for non\u2010invasive respiratory monitoring and evaluation of neuromuscular disease. <jats:italic>Muscle Nerve<\/jats:italic> 50: 607\u2013609, 2014<\/jats:p>","DOI":"10.1002\/mus.24294","type":"journal-article","created":{"date-parts":[[2014,5,23]],"date-time":"2014-05-23T18:56:19Z","timestamp":1400871379000},"page":"607-609","source":"Crossref","is-referenced-by-count":12,"title":["Ultrasound assessment of the diaphragm: Preliminary study of a canine model of X\u2010linked myotubular myopathy"],"prefix":"10.1002","volume":"50","author":[{"given":"Aarti","family":"Sarwal","sequence":"first","affiliation":[{"name":"Department of Neurology Wake Forest School of Medicine, Medical Center Boulevard Winston\u2010Salem North Carolina 27157 USA"},{"name":"Department of Anesthesiology Section on Critical Care, Wake Forest School of Medicine Winston\u2010Salem North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael S.","family":"Cartwright","sequence":"additional","affiliation":[{"name":"Department of Neurology Wake Forest School of Medicine, Medical Center Boulevard Winston\u2010Salem North Carolina 27157 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francis O.","family":"Walker","sequence":"additional","affiliation":[{"name":"Department of Neurology Wake Forest School of Medicine, Medical Center Boulevard Winston\u2010Salem North Carolina 27157 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erin","family":"Mitchell","sequence":"additional","affiliation":[{"name":"Wake Forest University Animal Resources Program Wake Forest School of Medicine Winston\u2010Salem North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Buj\u2010Bello","sequence":"additional","affiliation":[{"name":"G\u00e9n\u00e9thon, INSERM, Evry  France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan H.","family":"Beggs","sequence":"additional","affiliation":[{"name":"Division of Genetics and Genomics, The Manton Center for Orphan Disease Research Boston Children's Hospital, Harvard Medical School Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin K.","family":"Childers","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine Institute for Stem Cell and Regenerative Medicine, School of Medicine, University of Washington Seattle Washington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,8,30]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2466-4-8"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1986.61.5.1815"},{"key":"e_1_2_6_4_1","first-page":"753","article-title":"Respiratory muscle length measured by sonomicrometry","volume":"56","author":"Newman S","year":"1984","journal-title":"J Appl Physiol Respir Environ Exerc Physiol"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2009.05.008"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/vaa.12073"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740-8261.2003.tb01276.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.23671"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2003.10.022"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3007523"},{"key":"e_1_2_6_11_1","first-page":"36","article-title":"Imaging processing with ImageJ","volume":"11","author":"Abr\u00e0moff MD","year":"2004","journal-title":"Biophoton Int"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.7863\/jum.1993.12.2.73"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.7863\/jum.2001.20.6.597"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.21187"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.21015"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.7863\/jum.1988.7.9.505"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.10385"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1007236"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e3182266408"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1997.83.1.291"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0195-5616(98)50086-1"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddt003"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.23463"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pmr.2011.11.017"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1003677107"}],"container-title":["Muscle &amp; Nerve"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmus.24294","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.24294","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T05:26:20Z","timestamp":1696397180000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mus.24294"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8,30]]},"references-count":24,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,10]]}},"alternative-id":["10.1002\/mus.24294"],"URL":"https:\/\/doi.org\/10.1002\/mus.24294","archive":["Portico"],"relation":{},"ISSN":["0148-639X","1097-4598"],"issn-type":[{"value":"0148-639X","type":"print"},{"value":"1097-4598","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,8,30]]}}}