{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T22:24:23Z","timestamp":1778883863998,"version":"3.51.4"},"reference-count":13,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,9,24]],"date-time":"2014-09-24T00:00:00Z","timestamp":1411516800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008087","name":"Guthy-Jackson Charitable Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100008087","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Neuromyelitis optica (NMO) is characterized by inflammatory demyelinating lesions of the spinal cord and optic nerves from an autoimmune response against water channel aquaporin\u20104 (<jats:italic>AQP4<\/jats:italic>). We report 2 patients with transient hyperCKemia associated with NMO suggesting possible skeletal muscle damage. <jats:italic>Methods<\/jats:italic>: Patient 1 was a 72\u2010year\u2010old man who presented with muscle soreness and elevated serum creatine kinase (CK) preceding an initial attack of NMO. Patient 2 was a 25\u2010year\u2010old woman with an established diagnosis of NMO who presented with diffuse myalgias, proximal upper extremity weakness, and hyperCKemia. Muscle biopsies were obtained for histopathologic evaluation, protein gel electrophoresis, immunofluorescence, and complement staining. <jats:italic>Results<\/jats:italic>: In both patients the muscle showed only mild variation in fiber diameter. There were no inflammatory changes or muscle fiber necrosis, though there was reduced <jats:italic>AQP4<\/jats:italic> expression and deposition of activated complement. <jats:italic>Conclusions<\/jats:italic>: Complement\u2010mediated sarcolemmal injury may lead to hyperCKemia in NMO. <jats:italic>Muscle Nerve<\/jats:italic> <jats:bold>50<\/jats:bold>: 859\u2013862, 2014<\/jats:p><\/jats:sec>","DOI":"10.1002\/mus.24298","type":"journal-article","created":{"date-parts":[[2014,5,23]],"date-time":"2014-05-23T18:43:40Z","timestamp":1400870620000},"page":"859-862","source":"Crossref","is-referenced-by-count":29,"title":["Transient hyperckemia in the setting of neuromyelitis optica (NMO)"],"prefix":"10.1002","volume":"50","author":[{"given":"Rabia","family":"Malik","sequence":"first","affiliation":[{"name":"UCSF, Neurology 505 Parnassus Avenue Box 0114 M\u2010798 San Francisco California USA 94143"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aaron","family":"Lewis","sequence":"additional","affiliation":[{"name":"Department of Neurology Kaiser Permanente San Francisco California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruce A.C.","family":"Cree","sequence":"additional","affiliation":[{"name":"UCSF, Neurology 505 Parnassus Avenue Box 0114 M\u2010798 San Francisco California USA 94143"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julien","family":"Ratelade","sequence":"additional","affiliation":[{"name":"Departments of Medicine and Physiology UCSF Medical Center San Francisco California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Rossi","sequence":"additional","affiliation":[{"name":"Departments of Medicine and Physiology UCSF Medical Center San Francisco California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan S.","family":"Verkman","sequence":"additional","affiliation":[{"name":"Departments of Medicine and Physiology UCSF Medical Center San Francisco California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew W.","family":"Bollen","sequence":"additional","affiliation":[{"name":"Division of Neuropathology, Department of Pathology UCSF Medical Center San Francisco California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey W.","family":"Ralph","sequence":"additional","affiliation":[{"name":"UCSF, Neurology 505 Parnassus Avenue Box 0114 M\u2010798 San Francisco California USA 94143"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,9,24]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(12)70133-3"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-med-043010-193843"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181dd445b"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.51.7898"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0854.2011.01299.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0027412"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182698d39"},{"key":"e_1_2_7_9_1","volume-title":"Presented at the 28th Congress of the European Committee for Treatment and Research in Multiple Sclerosis","author":"Grouse CK","year":"2012"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.01-0797fje"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.4161\/cc.7.14.6272"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000289761.64862.ce"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awp309"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.297275"}],"container-title":["Muscle &amp; Nerve"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmus.24298","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.24298","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T07:32:32Z","timestamp":1696404752000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mus.24298"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9,24]]},"references-count":13,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,11]]}},"alternative-id":["10.1002\/mus.24298"],"URL":"https:\/\/doi.org\/10.1002\/mus.24298","archive":["Portico"],"relation":{},"ISSN":["0148-639X","1097-4598"],"issn-type":[{"value":"0148-639X","type":"print"},{"value":"1097-4598","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,9,24]]}}}