{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T02:53:04Z","timestamp":1785466384125,"version":"3.56.0"},"reference-count":47,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,1,6]],"date-time":"2015-01-06T00:00:00Z","timestamp":1420502400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Grants-in-Aid for Scientific Research","award":["19300196, 22300189, 25282165"],"award-info":[{"award-number":["19300196, 22300189, 25282165"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p><jats:italic>Introduction<\/jats:italic>: We determined the effects of low\u2010intensity exercise on the three\u2010dimensional capillary structure and associated angiogenic factors in the soleus muscle of Goto\u2010Kakizaki (GK) diabetic rats. <jats:italic>Methods<\/jats:italic>: Four groups of male rats were studied: sedentary nondiabetic (Con), exercised nondiabetic control (Ex), sedentary GK, and exercised GK (GK+Ex). Rats in the Ex and GK+Ex groups were subjected to chronic low\u2010intensity running on a treadmill (15 m\/min, 60 min\/session, 5 sessions\/week for 3 weeks). <jats:italic>Results<\/jats:italic>: Although mean capillary volume and diameter were lower in the GK compared with all other groups, low\u2010intensity exercise increased both of these measures in GK rats. Mitochondrial markers, <jats:italic>i.e<\/jats:italic>., SDH activity and PGC\u20101\u03b1 expression, and the levels of angiogenic factors were higher in the GK+Ex than all other groups. Exercise increased vascular endothelial growth factor (VEGF) protein levels and the VEGF\u2010to\u2010TSP\u20101 ratio, an indicator of angiogenesis, in GK rats. <jats:italic>Conclusions<\/jats:italic>: Combined, the results indicate that low\u2010intensity exercise reduces some of the microcirculatory complications in type 2 diabetic muscles. <jats:italic>Muscle Nerve<\/jats:italic> 51: 391\u2013399, 2015<\/jats:p>","DOI":"10.1002\/mus.24316","type":"journal-article","created":{"date-parts":[[2014,6,11]],"date-time":"2014-06-11T11:42:07Z","timestamp":1402486927000},"page":"391-399","source":"Crossref","is-referenced-by-count":27,"title":["Low\u2010intensity running exercise enhances the capillary volume and pro\u2010angiogenic factors in the soleus muscle of type 2 diabetic rats"],"prefix":"10.1002","volume":"51","author":[{"given":"Hiroyo","family":"Kondo","sequence":"first","affiliation":[{"name":"Department of Food Science and Nutrition Nagoya Women's University Nagoya 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