{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T09:23:10Z","timestamp":1789982590750,"version":"4.0.1"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,1,29]],"date-time":"2015-01-29T00:00:00Z","timestamp":1422489600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"the Korea Healthcare technology R&D Project, Ministry for Health,Welfare & Family Affairs, Republic of Korea","award":["HI13C1334"],"award-info":[{"award-number":["HI13C1334"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p><jats:italic>Introduction<\/jats:italic>: Split hand is considered to be a specific feature of amyotrophic lateral sclerosis (ALS). <jats:italic>Methods<\/jats:italic>: We evaluated the pattern difference of intrinsic hand muscles of upper limb\u2010onset ALS (UL\u2010ALS), upper limb\u2010onset progressive muscular atrophy (UL\u2010PMA), brachial amyotrophic diplegia (BAD), and Hirayama disease (HD) by measuring objective electrophysiological markers. <jats:italic>Results<\/jats:italic>: The abductor digiti minimi (ADM)\/abductor pollicis brevis (APB) compound muscle action potential (CMAP) amplitude ratio was significantly higher in UL\u2010ALS than other variants, but a considerable proportion of UL\u2010ALS cases had an amplitude ratio in the range of other variants. Absent APB CMAP and abnormally high ADM\/APB CMAP amplitude ratio (\u22654) occurred only with UL\u2010ALS. Conversely, an absent ADM CMAP was identified only in UL\u2010PMA and BAD. <jats:italic>Conclusions<\/jats:italic>: The absolute ADM\/APB CMAP amplitude ratio was not specific for ALS; however, several findings from simple electrophysiological measurements may help predict prognosis in patients with motor neuron diseases and may be early diagnostic markers for ALS. <jats:italic>Muscle Nerve<\/jats:italic> 51: 333\u2013337, 2015<\/jats:p>","DOI":"10.1002\/mus.24323","type":"journal-article","created":{"date-parts":[[2014,6,24]],"date-time":"2014-06-24T09:18:07Z","timestamp":1403601487000},"page":"333-337","source":"Crossref","is-referenced-by-count":22,"title":["Pattern difference of dissociated hand muscle atrophy in amyotrophic lateral sclerosis and variants"],"prefix":"10.1002","volume":"51","author":[{"given":"Jee\u2010Eun","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Neurology Seoul Medical Center Seoul Republic of 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