{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T09:07:17Z","timestamp":1774343237998,"version":"3.50.1"},"reference-count":8,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,1,9]],"date-time":"2015-01-09T00:00:00Z","timestamp":1420761600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p><jats:italic>Introduction<\/jats:italic>: Isolated peripheral motor dysfunction due to lower motor neuron or peripheral nerve disorders presents an interesting challenge to clinicians because of the diverse differential diagnosis with a broad range of prognoses. <jats:italic>Methods<\/jats:italic>: We retrospectively reviewed clinical data of adults who presented over 12 years with muscle weakness, atrophy, or fasciculations, but without hyperreflexia or sensory involvement. <jats:italic>Results<\/jats:italic>: In 119 patients, 52% had a motor neuron disease (MND), 13% had immune neuropathies, 11% had genetic neuronopathies, 10% had residual or post\u2010polio syndrome, 5% had benign fasciculation, 1% had an infectious etiology, and 8% were not given a final diagnosis. Only MND patients had cognitive dysfunction or frontal release signs. Bulbar and respiratory symptoms virtually excluded consideration of immune neuropathy. <jats:italic>Conclusions<\/jats:italic>: Only half of the patients were diagnosed with MND. A significant minority have treatable conditions. Cognitive involvement, frontal release signs, and bulbar or respiratory symptoms are strongly suggestive of MND. <jats:italic>Muscle Nerve<\/jats:italic> 51: 358\u2013362, 2015<\/jats:p>","DOI":"10.1002\/mus.24326","type":"journal-article","created":{"date-parts":[[2014,7,5]],"date-time":"2014-07-05T09:55:24Z","timestamp":1404554124000},"page":"358-362","source":"Crossref","is-referenced-by-count":15,"title":["The clinical spectrum of isolated peripheral motor dysfunction"],"prefix":"10.1002","volume":"51","author":[{"given":"Alan B.","family":"Sanderson","sequence":"first","affiliation":[{"name":"Department of Neurology Division of Neuromuscular Medicine The Ohio State University Wexner Medical Center 395 West 12th Avenue, 7th Floor Columbus Ohio 43210 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. David","family":"Arnold","sequence":"additional","affiliation":[{"name":"Department of Neurology Division of Neuromuscular Medicine The Ohio State University Wexner Medical Center 395 West 12th Avenue, 7th Floor Columbus Ohio 43210 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bakri","family":"Elsheikh","sequence":"additional","affiliation":[{"name":"Department of Neurology Division of Neuromuscular Medicine The Ohio State University Wexner Medical Center 395 West 12th Avenue, 7th Floor Columbus Ohio 43210 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John T.","family":"Kissel","sequence":"additional","affiliation":[{"name":"Department of Neurology Division of Neuromuscular Medicine The Ohio State University Wexner Medical Center 395 West 12th Avenue, 7th Floor Columbus Ohio 43210 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,1,9]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-003-0235-9"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.57.1.109"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.58.11.1593"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.3109\/21678421.2013.771367"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1994.00540140104020"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0027041"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181c1dea3"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/146608200300079536"}],"container-title":["Muscle &amp; Nerve"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmus.24326","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmus.24326","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.24326","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T02:07:11Z","timestamp":1696558031000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mus.24326"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1,9]]},"references-count":8,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,3]]}},"alternative-id":["10.1002\/mus.24326"],"URL":"https:\/\/doi.org\/10.1002\/mus.24326","archive":["Portico"],"relation":{},"ISSN":["0148-639X","1097-4598"],"issn-type":[{"value":"0148-639X","type":"print"},{"value":"1097-4598","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,1,9]]}}}