{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T05:03:09Z","timestamp":1784178189327,"version":"3.55.0"},"reference-count":10,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,2,24]],"date-time":"2015-02-24T00:00:00Z","timestamp":1424736000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p><jats:italic>Introduction<\/jats:italic>: Animal studies have shown inhibitory connections between the sensory trigeminal nucleus and hypoglossal nucleus. I investigated whether these inhibitory projections are present in humans. <jats:italic>Methods<\/jats:italic>: I examined 18 healthy subjects, 2 patients with brainstem stroke, and 5 patients with multiple sclerosis using a specially designed oral stimulation and recording device. <jats:italic>Results<\/jats:italic>: In 16 of 18 subjects, a bilateral suppression period of tongue muscle activity after unilateral electrical stimulation of the mucosal V2 afferents was observed. The silent period started at 31.1 (SD 4.7) ms (ipsilateral) and 32.0 (SD 4.9) ms (contralateral). The mean duration of the silent period was 31.4 (SD 10.2) ms (ispilateral) and 32.5 (SD 9.8) ms (contralateral). Patients with dorsolateral pontomedullary lesions had ipsilateral absence of the silent period. <jats:italic>Conclusions<\/jats:italic>: This study confirms the existence of a bilateral trigeminal\u2010hypoglossal silent period in humans. <jats:italic>Muscle Nerve<\/jats:italic> 51: 538\u2013540, 2015<\/jats:p>","DOI":"10.1002\/mus.24349","type":"journal-article","created":{"date-parts":[[2014,7,25]],"date-time":"2014-07-25T05:27:09Z","timestamp":1406266029000},"page":"538-540","source":"Crossref","is-referenced-by-count":5,"title":["Trigeminal\u2010hypoglossal silent period: A pontomedullary brainstem reflex"],"prefix":"10.1002","volume":"51","author":[{"given":"Peter P.","family":"Urban","sequence":"first","affiliation":[{"name":"Department of Neurology Asklepios Klinik Barmbek R\u00fcbenkamp 220 22291 Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,2,24]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(98)00758-1"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/syn.10227"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2006.04858.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0025615"},{"key":"e_1_2_6_6_1","doi-asserted-by":"crossref","first-page":"197\u2013204","DOI":"10.1016\/0006-8993(88)90764-0","article-title":"A horseradish peroxidase study of the central projections of primary trigeminal neurons innervating the hard palate in the cat","volume":"451","author":"Arvidsson J","year":"1988","journal-title":"Brain Res"},{"key":"e_1_2_6_7_1","doi-asserted-by":"crossref","first-page":"324\u2013331","DOI":"10.1016\/0014-4886(91)90099-X","article-title":"Difference in central projection of primary afferents innervating facial and intraoral structures in the rat","volume":"111","author":"Takemura M","year":"1991","journal-title":"Exp Neurol"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4598(200006)23:6<939::AID-MUS15>3.0.CO;2-7"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNP.0b013e3181d65031"},{"key":"e_1_2_6_10_1","first-page":"781\u2013792","article-title":"Effects of brainstem lesions on the masseter inhibitory reflex","volume":"113","author":"Ongerboer de Visser BW","year":"1989","journal-title":"Brain"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.67.5.630"}],"container-title":["Muscle &amp; Nerve"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmus.24349","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmus.24349","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.24349","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T16:27:58Z","timestamp":1695572878000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mus.24349"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2,24]]},"references-count":10,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,4]]}},"alternative-id":["10.1002\/mus.24349"],"URL":"https:\/\/doi.org\/10.1002\/mus.24349","archive":["Portico"],"relation":{},"ISSN":["0148-639X","1097-4598"],"issn-type":[{"value":"0148-639X","type":"print"},{"value":"1097-4598","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,2,24]]}}}