{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T19:10:00Z","timestamp":1792696200648,"version":"4.5.0"},"reference-count":21,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,3,31]],"date-time":"2015-03-31T00:00:00Z","timestamp":1427760000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Autonomic Disorders Program Project","award":["NS 32352"],"award-info":[{"award-number":["NS 32352"]}]},{"name":"Pathogenesis and Diagnosis of Multiple System Atrophy","award":["NS 44233"],"award-info":[{"award-number":["NS 44233"]}]},{"name":"Autonomic Rare Disease Clinical Consortium","award":["U54 NS065736"],"award-info":[{"award-number":["U54 NS065736"]}]},{"name":"NPS","award":["CA 169443"],"award-info":[{"award-number":["CA 169443"]}]},{"name":"Mayo CTSA","award":["UL1 TR000135"],"award-info":[{"award-number":["UL1 TR000135"]}]},{"name":"Mayo Funds"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p><jats:italic>Introduction<\/jats:italic>: The aim of this study is to characterize autonomic impairment in motor neuron disease. <jats:italic>Methods<\/jats:italic>: Neurological evaluations and autonomic testing were analyzed retrospectively in 132 patients: 86 classic amyotrophic lateral sclerosis (ALS), 36 lower motor neuron (LMN), and 10 upper motor neuron (UMN) predominant disease. <jats:italic>Results<\/jats:italic>: One\u2010third of patients were symptomatic; urinary urgency and constipation were the most frequent symptoms. Increased Composite Autonomic Severity Score (CASS) was present in 75% with mild impairment (CASS 1\u20133) in 85% and moderate (CASS 4\u20137) in 15%. The frequencies of testing abnormalities were: sudomotor 46%, cardiovagal 50%, and adrenergic 14%. The UMN group had significantly higher median CASS scores than the classic ALS (<jats:italic>P<\/jats:italic>\u2009=\u20090.021) and LMN group (<jats:italic>P<\/jats:italic>\u2009=\u20090.018). <jats:italic>Conclusions<\/jats:italic>: We found predominantly mild autonomic impairment in ALS patients, with mostly cardiovagal and sudomotor involvement. Moderate autonomic failure occurred in 1 of 7 patients, especially those with an UMN presentation. Patients with selective corticospinal tract involvement may have more impairment of autonomic pathways. <jats:italic>Muscle Nerve<\/jats:italic> <jats:bold>51<\/jats:bold>:676\u2013679, 2015<\/jats:p>","DOI":"10.1002\/mus.24457","type":"journal-article","created":{"date-parts":[[2014,9,11]],"date-time":"2014-09-11T13:45:39Z","timestamp":1410443139000},"page":"676-679","source":"Crossref","is-referenced-by-count":100,"title":["Autonomic system and amyotrophic lateral sclerosis"],"prefix":"10.1002","volume":"51","author":[{"given":"Ezequiel A.","family":"Piccione","sequence":"first","affiliation":[{"name":"Department of Neurology Mayo Clinic 200 First Street SW Rochester Minnesota USA 55905"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M.","family":"Sletten","sequence":"additional","affiliation":[{"name":"Department of Neurology Mayo Clinic 200 First Street SW Rochester Minnesota USA 55905"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan P.","family":"Staff","sequence":"additional","affiliation":[{"name":"Department of Neurology Mayo Clinic 200 First Street SW Rochester Minnesota USA 55905"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phillip A.","family":"Low","sequence":"additional","affiliation":[{"name":"Department of Neurology Mayo Clinic 200 First Street SW Rochester Minnesota USA 55905"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,3,31]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2013.221"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2006.098533"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000286948.99150.16"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.25.8.781"},{"key":"e_1_2_7_6_1","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1097\/00004691-199301000-00003","article-title":"Autonomic nervous system function","volume":"10","author":"Low PA","year":"1993","journal-title":"J Clin Neurophysiol"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-6196(12)60631-4"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182494d66"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(94)90191-0"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/146608200300079536"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/146608299300079484"},{"key":"e_1_2_7_12_1","first-page":"174","article-title":"Increased prevalence of bladder and intestinal dysfunction in amyotrophic lateral sclerosis","volume":"15","author":"N\u00fcbling GS","year":"2014","journal-title":"Amyotroph Lateral Scler Other Motor Neuron Disord"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.48.11.1103"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-510X(96)05313-0"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00314326"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880181103"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.73.1.68"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1080\/146608201316949550"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31821e553a"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(94)90094-9"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1985.tb03215.x"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.49.4.1031"}],"container-title":["Muscle &amp; Nerve"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmus.24457","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.24457","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T05:55:45Z","timestamp":1696398945000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mus.24457"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3,31]]},"references-count":21,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015,5]]}},"alternative-id":["10.1002\/mus.24457"],"URL":"https:\/\/doi.org\/10.1002\/mus.24457","archive":["Portico"],"relation":{},"ISSN":["0148-639X","1097-4598"],"issn-type":[{"value":"0148-639X","type":"print"},{"value":"1097-4598","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3,31]]}}}