{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:24:50Z","timestamp":1788870290995,"version":"build-2803163510"},"reference-count":48,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,5,23]],"date-time":"2015-05-23T00:00:00Z","timestamp":1432339200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["#1039520"],"award-info":[{"award-number":["#1039520"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008714","name":"Motor Neurone Disease Research Institute of Australia","doi-asserted-by":"crossref","award":["#1039520"],"award-info":[{"award-number":["#1039520"]}],"id":[{"id":"10.13039\/100008714","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Presentations to the neuromuscular clinic commonly involve hand muscle denervation, but few studies have evaluated hand muscle ultrasound.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Ultrasound studies of abductor pollicis brevis, first dorsal interosseous, and abductor digit minimi were prospectively performed in a cohort of 34 patients (77 muscles) with electromyography (EMG)\u2010confirmed denervation, compared with 58 healthy control subjects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In control subjects, muscle thickness was highly reproducible [intraclass correlation coefficient (ICC)\u2009=\u20090.88\u20130.98], and echogenicity was moderately reproducible (ICC\u2009=\u20090.542\u20130.686). Age, gender, and body mass index influenced muscle thickness and echogenicity. Ultrasound changes in denervated muscles correlated with the severity of EMG abnormalities. A z\u2010score cutoff of 0 identified denervated muscles with a sensitivity of 100% and 89% for echogenicity and muscle thickness, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Hand muscle ultrasound provides a noninvasive method to quantify muscle denervation and may be useful as a screening tool before EMG studies.\n                      <jats:italic>Muscle Nerve<\/jats:italic>\n                      <jats:bold>52<\/jats:bold>\n                      : 221\u2013230, 2015\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mus.24519","type":"journal-article","created":{"date-parts":[[2014,11,11]],"date-time":"2014-11-11T11:37:26Z","timestamp":1415705846000},"page":"221-230","source":"Crossref","is-referenced-by-count":52,"title":["Quantitative ultrasound of denervated hand muscles"],"prefix":"10.1002","volume":"52","author":[{"given":"Neil G.","family":"Simon","sequence":"first","affiliation":[{"name":"Department of Neurology University of California San Francisco, San Francisco California USA"},{"name":"Neuroscience Research Australia PO Box 1165, Randwick NSW 2031 Australia"},{"name":"Prince of Wales Clinical School, University of New South Wales  Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey W.","family":"Ralph","sequence":"additional","affiliation":[{"name":"Department of Neurology University of California San Francisco, San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Lomen\u2010Hoerth","sequence":"additional","affiliation":[{"name":"Department of Neurology University of California San Francisco, San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann 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