{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T02:33:35Z","timestamp":1773023615319,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,1,16]],"date-time":"2015-01-16T00:00:00Z","timestamp":1421366400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p><jats:italic>Introduction<\/jats:italic>: Skeletal muscle is common in late\u2010onset Pompe disease (LOPD). Recent data implicate common bulbar muscle involvement (i.e., the tongue). <jats:italic>Methods<\/jats:italic>: We used quantitative assessment of lingual strength to retrospectively determine the frequency and severity of lingual weakness in LOPD. We additionally examined associations between lingual strength and the presence or absence of dysarthria, and dysarthria severity. <jats:italic>Results<\/jats:italic>: Quantitative assessment revealed lingual weakness to be present in 80% of the sample. In the 24 affected patients, severity was mild in 29%, moderate in 29%, and severe in 42%. Patients with clinical dysarthria had greater lingual weakness than those without. As dysarthria severity increased, lingual strength decreased by an average of 6.82 kPa. <jats:italic>Conclusions<\/jats:italic>: These quantitative data provide additional evidence for presence of bulbar muscle disease in patients with LOPD. Further study is necessary to determine functional effects, temporal progression, and effects of treatment. <jats:italic>Muscle Nerve<\/jats:italic> <jats:bold>51<\/jats:bold>:731\u2013735, 2015<\/jats:p>","DOI":"10.1002\/mus.24523","type":"journal-article","created":{"date-parts":[[2014,11,15]],"date-time":"2014-11-15T17:19:23Z","timestamp":1416071963000},"page":"731-735","source":"Crossref","is-referenced-by-count":27,"title":["Quantitative assessment of lingual strength in late\u2010onset Pompe disease"],"prefix":"10.1002","volume":"51","author":[{"given":"Harrison N.","family":"Jones","sequence":"first","affiliation":[{"name":"Department of Surgery Division of Speech Pathology &amp; Audiology 155 Baker House Trent Drive DUMC 3887 Durham North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelly D.","family":"Crisp","sequence":"additional","affiliation":[{"name":"Duke Speech Pathology &amp; Audiology Duke University Hospital Durham North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Priyanka","family":"Asrani","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Division of Medical Genetics, Duke University Durham North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Sloane","sequence":"additional","affiliation":[{"name":"Study of Aging and Human Development Duke University Medical Center Durham North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Priya S.","family":"Kishnani","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Division of Medical Genetics, Duke University Durham North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,1,16]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.gim.0000218152.87434.f3"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-009-5275-3"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2012.09.015"},{"key":"e_1_2_6_5_1","first-page":"147","article-title":"Language and speech function in children with infantile Pompe disease","volume":"7","author":"Muller CS","year":"2009","journal-title":"J Pediatr Neurol"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/91.3.435"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880100311"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-199505000-00002"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.105.3.947"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2011.06.748"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.22202"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2007.07.011"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2007.03.014"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00455-013-9451-3"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1044\/1092-4388(2010\/09-0068)"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00455-012-9436-7"},{"key":"e_1_2_6_17_1","unstructured":"WA: IOPI Medical. IOPI Medical. IOPI User Manual 2.2. Redmond"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00455-009-9215-2"},{"key":"e_1_2_6_19_1","unstructured":"MO: Elsevier Mosby 2013 Duffy J. Motor speech disorders: substrates differential diagnosis and management. St Louis"},{"key":"e_1_2_6_20_1","unstructured":"Texas: Pro\u2010ed 2010 Yorkston KM BD Strand EA Hakel M. Management of motor speech disorders in children and adults. Austin"},{"key":"e_1_2_6_21_1","unstructured":"and Health. Geneva: WHO 2001 World Health Organization. ICF: International Classification of Functioning Disability"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.25054"}],"container-title":["Muscle &amp; Nerve"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmus.24523","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.24523","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T05:55:52Z","timestamp":1696398952000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mus.24523"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1,16]]},"references-count":21,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015,5]]}},"alternative-id":["10.1002\/mus.24523"],"URL":"https:\/\/doi.org\/10.1002\/mus.24523","archive":["Portico"],"relation":{},"ISSN":["0148-639X","1097-4598"],"issn-type":[{"value":"0148-639X","type":"print"},{"value":"1097-4598","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,1,16]]}}}