{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T18:28:48Z","timestamp":1793298528711,"version":"4.5.0"},"reference-count":13,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,5,23]],"date-time":"2015-05-23T00:00:00Z","timestamp":1432339200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"A.P. M\u00c3\u00b8ller Foundation for the Advancement of Medical Sciences"},{"name":"Hans and Nora Buchards Foundation"},{"name":"The Vanf\u00c3\u00b8re Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>In this study we investigated the effect of 12 weeks of cycle ergometer training in patients with spinal muscular atrophy type III (SMA III), a hereditary motor neuron disease with progressive muscle weakness and atrophy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Six SMA III patients and 9 healthy subjects completed a 12\u2010week training program, performing 42 30\u2010minute sessions exercising at 65\u201370% of maximal oxygen uptake (V<jats:sc>O<\/jats:sc><jats:sub>2max<\/jats:sub>). V<jats:sc>O<\/jats:sc><jats:sub>2max<\/jats:sub>, muscle strength, functional tests, and self\u2010reported activities of daily living were assessed before and after the training.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Training induced a 27\u2009\u00b1\u20093% increase in V<jats:sc>O<\/jats:sc><jats:sub>2max<\/jats:sub> (17\u2009\u00b1\u20092 to 21\u2009\u00b1\u20092 ml\/kg\/min, <jats:italic>P &lt;<\/jats:italic> 0.001) in patients. However, fatigue was a major complaint and caused 1 patient to drop out, increased the need for sleep in 3 patients, and led to training modifications in 2 patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Cycle exercise improves V<jats:sc>O<\/jats:sc><jats:sub>2max<\/jats:sub> in SMA III without causing muscle damage, but it also induces significant fatigue. This warrants study into alternative training methods to improve exercise capacity in SMA III patients. <jats:italic>Muscle Nerve<\/jats:italic> <jats:bold>52<\/jats:bold>: 240\u2013244, 2015<\/jats:p><\/jats:sec>","DOI":"10.1002\/mus.24527","type":"journal-article","created":{"date-parts":[[2014,11,24]],"date-time":"2014-11-24T09:42:33Z","timestamp":1416822153000},"page":"240-244","source":"Crossref","is-referenced-by-count":52,"title":["Training improves oxidative capacity, but not function, in spinal muscular atrophy type III"],"prefix":"10.1002","volume":"52","author":[{"given":"Karen Lindhardt","family":"Madsen","sequence":"first","affiliation":[{"name":"Department of Neuromuscular Research Unit Section 3342 Rigshospitalet and University of Copenhagen Blegdamsvej 9, DK\u20102100 Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Regitze S\u00f8lling","family":"Hansen","sequence":"additional","affiliation":[{"name":"Department of Neuromuscular Research Unit Section 3342 Rigshospitalet and University of Copenhagen Blegdamsvej 9, DK\u20102100 Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolai","family":"Preisler","sequence":"additional","affiliation":[{"name":"Department of Neuromuscular Research Unit Section 3342 Rigshospitalet and University of Copenhagen Blegdamsvej 9, DK\u20102100 Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Th\u00f8gersen","sequence":"additional","affiliation":[{"name":"Department of Neuromuscular Research Unit Section 3342 Rigshospitalet and University of Copenhagen Blegdamsvej 9, DK\u20102100 Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin Peter","family":"Berthelsen","sequence":"additional","affiliation":[{"name":"Department of Neuromuscular Research Unit Section 3342 Rigshospitalet and University of Copenhagen Blegdamsvej 9, DK\u20102100 Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Vissing","sequence":"additional","affiliation":[{"name":"Department of Neuromuscular Research Unit Section 3342 Rigshospitalet and University of Copenhagen Blegdamsvej 9, DK\u20102100 Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,5,23]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-8966(06)80015-5"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000150584.45055.27"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20460"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000250358.32199.24"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005650-199206000-00002"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.10050"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4598(199611)19:11<1391::AID-MUS3>3.0.CO;2-7"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000341274.61236.02"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.22106"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1995.03520380029031"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0838.2006.00520.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3237-07.2008"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1245-05.2005"}],"container-title":["Muscle &amp; Nerve"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmus.24527","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmus.24527","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.24527","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T21:37:52Z","timestamp":1696541872000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mus.24527"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5,23]]},"references-count":13,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,8]]}},"alternative-id":["10.1002\/mus.24527"],"URL":"https:\/\/doi.org\/10.1002\/mus.24527","archive":["Portico"],"relation":{},"ISSN":["0148-639X","1097-4598"],"issn-type":[{"value":"0148-639X","type":"print"},{"value":"1097-4598","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,5,23]]}}}