{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T11:54:39Z","timestamp":1775130879712,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,6,18]],"date-time":"2015-06-18T00:00:00Z","timestamp":1434585600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p><jats:italic>Introduction<\/jats:italic>: Myasthenia gravis (MG) can be refractory to conventional immunotherapy. We report on the efficacy and durability of intravenous (IV) remission\u2010induction cyclophosphamide (CYC) followed by oral immunosuppression in refractory MG. <jats:italic>Methods<\/jats:italic>: We identified 8 patients from our medical records with moderate or severe refractory MG who were treated with 6 cycles of IV CYC (0.75 g\/m<jats:sup>2<\/jats:sup>) every 4 weeks followed by oral immunosuppression. <jats:italic>Results<\/jats:italic>: Six patients improved within 3 months of treatment. Four patients remained in clinical remission (mean follow\u2010up 31 months). Two patients responded partially, and 1 patient relapsed after 11 months. Two patients were non\u2010responders. CYC was well tolerated. Acetylcholine receptor antibody levels remained below pretreatment levels in patients in clinical remission. The leukocyte nadir was lower in CYC responders. <jats:italic>Conclusions<\/jats:italic>: Remission\u2010induction IV CYC followed by oral immunosuppression is a rapid, effective, and durable treatment for refractory MG. Adding a post\u2010CYC immunosuppressant may account for low relapse rates compared with other published series. <jats:italic>Muscle Nerve<\/jats:italic> <jats:bold>52<\/jats:bold>: 204\u2013210, 2015<\/jats:p>","DOI":"10.1002\/mus.24536","type":"journal-article","created":{"date-parts":[[2014,12,9]],"date-time":"2014-12-09T15:36:31Z","timestamp":1418139391000},"page":"204-210","source":"Crossref","is-referenced-by-count":33,"title":["Induction intravenous cyclophosphamide followed by maintenance oral immunosuppression in refractory myasthenia gravis"],"prefix":"10.1002","volume":"52","author":[{"given":"Katherine A.","family":"Buzzard","sequence":"first","affiliation":[{"name":"Department of Neurology Concord Repatriation General Hospital Concord West New South Wales 2139 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas J.","family":"Meyer","sequence":"additional","affiliation":[{"name":"Department of Immunology Concord Repatriation General Hospital Concord West New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Todd A.","family":"Hardy","sequence":"additional","affiliation":[{"name":"Department of Neurology Concord Repatriation General Hospital Concord West New South Wales 2139 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. Sean","family":"Riminton","sequence":"additional","affiliation":[{"name":"Department of Immunology Concord Repatriation General Hospital Concord West New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen W.","family":"Reddel","sequence":"additional","affiliation":[{"name":"Department of Neurology Concord Repatriation General Hospital Concord West New South Wales 2139 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,6,18]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.31.1.32"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2003.019232"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.20411"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1405.033"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0b013e318210e685"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa020286"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa031855"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(00)01595-2"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181dc1b1e"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0b013e328346d47d"},{"key":"e_1_2_7_12_1","unstructured":"RimintonDS ReddelS MarshallR. 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