{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T08:36:37Z","timestamp":1781080597909,"version":"3.54.1"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,7,2]],"date-time":"2015-07-02T00:00:00Z","timestamp":1435795200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Department of Technology Development and Commercialization in the Research Institute at Nationwide Children's Hospital"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Traditional upper extremity measures typically focus on distal abilities and do not quantify the unique progression of decline in dystrophinopathy. We designed ACTIVE\u2010seated to meet this need. Our objective was to establish the tool's validity and reliability.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>ACTIVE\u2010seated uses the Microsoft Kinect gaming interface to quantify functional reaching ability while playing a custom\u2010designed game. A skeletal tracking algorithm was used to determine the furthest arm excursion in all planes in 61 subjects with dystrophinopathy and 16 controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Total reachable area was scaled based on arm length to standardize comparisons across subjects and accommodate growth. ACTIVE\u2010seated discriminately ranked subjects from normal controls and by Brooke level (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). Scores were highly correlated with parent reports of daily activities and mobility (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). Test\u2013retest reliability of ACTIVE\u2010seated was excellent (ICC\u2009=\u20090.97, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Initial evaluation of reliability and validity suggests that ACTIVE\u2010seated shows promise as a clinical and research outcome for individuals with dystrophinopathy. <jats:italic>Muscle Nerve<\/jats:italic> 52:356\u2013362, 2015<\/jats:p><\/jats:sec>","DOI":"10.1002\/mus.24557","type":"journal-article","created":{"date-parts":[[2014,12,30]],"date-time":"2014-12-30T23:43:34Z","timestamp":1419983014000},"page":"356-362","source":"Crossref","is-referenced-by-count":18,"title":["Reliability and validity of active\u2010seated: An outcome in dystrophinopathy"],"prefix":"10.1002","volume":"52","author":[{"given":"Linda P.","family":"Lowes","sequence":"first","affiliation":[{"name":"The Research Institute at Nationwide Children's Hospital Center for Gene Therapy 700 Children's Drive, AB0040 Columbus Ohio 43205 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsay N.","family":"Alfano","sequence":"additional","affiliation":[{"name":"The Research Institute at Nationwide Children's Hospital Center for Gene Therapy 700 Children's Drive, AB0040 Columbus Ohio 43205 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger","family":"Crawfis","sequence":"additional","affiliation":[{"name":"Department of Computer Science and Engineering The Ohio State University Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Berry","sequence":"additional","affiliation":[{"name":"The Research Institute at Nationwide Children's Hospital Center for Gene Therapy 700 Children's Drive, AB0040 Columbus Ohio 43205 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Yin","sequence":"additional","affiliation":[{"name":"The Research Institute at Nationwide Children's Hospital Biostatistics Core Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor","family":"Dvorchik","sequence":"additional","affiliation":[{"name":"The Research Institute at Nationwide Children's Hospital Biostatistics Core Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin M.","family":"Flanigan","sequence":"additional","affiliation":[{"name":"The Research Institute at Nationwide Children's Hospital Center for Gene Therapy 700 Children's Drive, AB0040 Columbus Ohio 43205 USA"},{"name":"Department of Pediatrics The Ohio State University College of Medicine Columbus Ohio USA"},{"name":"Department of Neurology The Ohio State University College of Medicine Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerry R.","family":"Mendell","sequence":"additional","affiliation":[{"name":"The Research Institute at Nationwide Children's Hospital Center for Gene Therapy 700 Children's Drive, AB0040 Columbus Ohio 43205 USA"},{"name":"Department of Pediatrics The Ohio State University College of Medicine Columbus Ohio USA"},{"name":"Department of Neurology The Ohio State University College of Medicine Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,7,2]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"Eli Lilly and Company. A study of Tadalafil for Duchenne muscular dystrophy. Available at:http:\/\/www.clinicaltrials.gov\/show\/NCT0 1865084\/."},{"key":"e_1_2_6_3_1","unstructured":"GlaxoSmithKline. A clinical study to assess the efficacy and safety of GSK2402968 in subjects with Duchenne muscular dystrophy (DMD114044). Available at:http:\/\/www.clinicaltrials.gov\/show\/NC01254019\/."},{"key":"e_1_2_6_4_1","unstructured":"Prosensa Therapeutics. Phase 2b study of PRO045 in subjects with Duchenne muscular dystrophy. Available at:http:\/\/clinicaltrials.gov\/show\/NCT01826474\/."},{"key":"e_1_2_6_5_1","unstructured":"Sarepta Therapeutics. Efficacy study of AVI\u20104658 to induce dystrophin expression in selected Duchenne muscular dystrophy patients. 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