{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T19:25:00Z","timestamp":1790277900417,"version":"4.1.0"},"reference-count":21,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,6,30]],"date-time":"2015-06-30T00:00:00Z","timestamp":1435622400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p><jats:italic>Introduction:<\/jats:italic> Antibody against the acetylcholine receptor of autonomic ganglia (gAChR\u2010Ab) is implicated in the pathogenesis of autoimmune autonomic ganglionopathy (AAG) and several other disorders. <jats:italic>Methods:<\/jats:italic> This study was a retrospective evaluation of 95 patients positive for gAChR\u2010Ab. <jats:italic>Results:<\/jats:italic> Twenty\u2010one (22%) patients had AAG, with a greater median gAChR\u2010Ab level (0.21 nmol\/L) and higher percentage (57%) of antibody levels &gt;0.20 nmol\/L when compared with the remaining 74 patients without autonomic manifestations (non\u2010AAG group, 0.10 nmol\/L and 15%, respectively). Only 2 new cases of malignancy were diagnosed after gAChR\u2010Ab detection. The non\u2010AAG group was associated with high frequencies of neurological and non\u2010neurological autoimmunity, but also included 23 (31%) patients with mostly degenerative disorders. <jats:italic>Conclusion:<\/jats:italic> Detection of gAChR\u2010Ab, especially at a higher level, is helpful for the diagnosis of AAG in patients with corresponding autonomic symptoms. However, its value is limited for predicting cancer risk and for diagnosis and management of patients without autonomic symptoms. <jats:italic>Muscle Nerve<\/jats:italic> 52:386\u2013391, 2015<\/jats:p>","DOI":"10.1002\/mus.24559","type":"journal-article","created":{"date-parts":[[2014,12,31]],"date-time":"2014-12-31T03:39:30Z","timestamp":1419997170000},"page":"386-391","source":"Crossref","is-referenced-by-count":48,"title":["Clinical experience of seropositive ganglionic acetylcholine receptor antibody in a tertiary neurology referral center"],"prefix":"10.1002","volume":"52","author":[{"given":"Yuebing","family":"Li","sequence":"first","affiliation":[{"name":"Department of Neurology Desk S90, Cleveland Clinic Foundation 9500 Euclid Avenue Cleveland Ohio 44195 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adham","family":"Jammoul","sequence":"additional","affiliation":[{"name":"Department of Neurology Desk S90, Cleveland Clinic Foundation 9500 Euclid Avenue Cleveland Ohio 44195 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Mente","sequence":"additional","affiliation":[{"name":"Department of Neurology Desk S90, Cleveland Clinic Foundation 9500 Euclid Avenue Cleveland Ohio 44195 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianbo","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Quantitative Health Sciences Learner Research Institute, Cleveland Clinic Foundation Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert W.","family":"Shields","sequence":"additional","affiliation":[{"name":"Department of Neurology Desk S90, Cleveland Clinic Foundation 9500 Euclid Avenue Cleveland Ohio 44195 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Vernino","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neurotherapeutics University of Texas Southwestern Medical Center Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Rae\u2010Grant","sequence":"additional","affiliation":[{"name":"Department of Neurology Desk S90, Cleveland Clinic Foundation 9500 Euclid Avenue Cleveland Ohio 44195 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,6,30]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200009213431204"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-6196(11)61027-6"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/08916930701619987"},{"key":"e_1_2_7_5_1","first-page":"735","article-title":"Ganglionic acetylcholine receptor autoantibody: oncological, neurological, and serological accompaniments","volume":"66","author":"See comment in PubMed Commons belowMcKeon A","year":"2009","journal-title":"Arch Neurol"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2008.12.002"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181bf995f"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02291236"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2013-305218"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI17429"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1485-04.2004"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10286-009-0012-7"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000312280.44805.5d"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2008.10.022"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-07-02522.2002"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2013.592"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.50.6.1806"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24189"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.05.2308"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21166"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2011-301237"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2009.181222"}],"container-title":["Muscle &amp; Nerve"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmus.24559","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmus.24559","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.24559","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T23:09:51Z","timestamp":1696374591000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mus.24559"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6,30]]},"references-count":21,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,9]]}},"alternative-id":["10.1002\/mus.24559"],"URL":"https:\/\/doi.org\/10.1002\/mus.24559","archive":["Portico"],"relation":{},"ISSN":["0148-639X","1097-4598"],"issn-type":[{"value":"0148-639X","type":"print"},{"value":"1097-4598","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6,30]]}}}