{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,22]],"date-time":"2026-03-22T03:04:55Z","timestamp":1774148695628,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,2,17]],"date-time":"2015-02-17T00:00:00Z","timestamp":1424131200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1R03AR061529-01"],"award-info":[{"award-number":["1R03AR061529-01"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p><jats:italic>Introduction<\/jats:italic>: Few studies of the demographics, natural history, and clinical management of inclusion body myositis (IBM) have been performed in a large patient population. To more accurately define these characteristics, we developed and distributed a questionnaire to patients with IBM. <jats:italic>Methods<\/jats:italic>: A cross\u2010sectional, self\u2010reporting survey was conducted. <jats:italic>Results<\/jats:italic>: The mean age of the 916 participants was 70.4 years, the male\u2010to\u2010female ratio was 2:1, and the majority reported difficulty with ambulation and activities of daily living. The earliest symptoms included impaired use and weakness of arms and legs. The mean time from first symptoms to diagnosis was 4.7 years. Half reported that IBM was their initial diagnosis. A composite functional index negatively associated with age and disease duration, and positively associated with participation in exercise. <jats:italic>Conclusions<\/jats:italic>: These data are valuable for informing patients how IBM manifestations are expected to impair daily living and indicate that self\u2010reporting could be used to establish outcome measures in clinical trials. <jats:italic>Muscle Nerve<\/jats:italic> 52: 527\u2013533, 2015<\/jats:p>","DOI":"10.1002\/mus.24562","type":"journal-article","created":{"date-parts":[[2014,12,31]],"date-time":"2014-12-31T04:33:21Z","timestamp":1420000401000},"page":"527-533","source":"Crossref","is-referenced-by-count":28,"title":["Demographic and clinical features of inclusion body myositis in north America"],"prefix":"10.1002","volume":"52","author":[{"given":"A. David","family":"Paltiel","sequence":"first","affiliation":[{"name":"Yale School of Public Health New Haven Connecticut USA"},{"name":"Yale School of Management New Haven Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Einar","family":"Ingvarsson","sequence":"additional","affiliation":[{"name":"Yale School of Management New Haven Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donald K. K.","family":"Lee","sequence":"additional","affiliation":[{"name":"Yale School of Management New Haven Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard L.","family":"Leff","sequence":"additional","affiliation":[{"name":"Richard L. Leff, MD, LLC Chadds Ford Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard J.","family":"Nowak","sequence":"additional","affiliation":[{"name":"Department of Neurology Yale School of Medicine 300 George Street, Room 353J New Haven Connecticut USA 06511"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kurt D.","family":"Petschke","sequence":"additional","affiliation":[{"name":"Yale School of Public Health New Haven Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seth","family":"Richards\u2010Shubik","sequence":"additional","affiliation":[{"name":"H. John Heinz III College, Carnegie Mellon University Pittsburgh Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ange","family":"Zhou","sequence":"additional","affiliation":[{"name":"Yale School of Management New Haven Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Shubik","sequence":"additional","affiliation":[{"name":"Yale School of Management New Haven Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin C.","family":"O'Connor","sequence":"additional","affiliation":[{"name":"Department of Neurology Yale School of Medicine 300 George Street, Room 353J New Haven Connecticut USA 06511"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,2,17]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0b013e328357f211"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2009.173823"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1586\/1744666X.2013.842467"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ker001"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/NEN.0b013e31826183c8"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002281-199711000-00007"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2013.08.007"},{"key":"e_1_2_7_9_1","first-page":"445","article-title":"Epidemiology of sporadic inclusion body myositis and polymyositis in Olmsted County, Minnesota","volume":"35","author":"Wilson FC","year":"2008","journal-title":"J Rheumatol"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2008.01.011"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-005-0884-y"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awr213"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2013.02.010"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1994.tb01647.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410400407"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.52.8910"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.20958"},{"issue":"3","key":"e_1_2_7_18_1","first-page":"727","article-title":"Inclusion body myositis","volume":"112","author":"Lotz BP","year":"1989","journal-title":"Observations in 40 patients. 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