{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:51:21Z","timestamp":1786978281969,"version":"build-2736575974"},"reference-count":60,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,6,3]],"date-time":"2015-06-03T00:00:00Z","timestamp":1433289600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 DC009890"],"award-info":[{"award-number":["R01 DC009890"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 DC0135470"],"award-info":[{"award-number":["R01 DC0135470"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["FRN126682"],"award-info":[{"award-number":["FRN126682"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009017","name":"ALS Society of Canada","doi-asserted-by":"crossref","award":["Discovery Grant"],"award-info":[{"award-number":["Discovery Grant"]}],"id":[{"id":"10.13039\/100009017","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Introduction<\/jats:italic>\n                    : Electrical impedance myography (EIM) quantifies muscle health and is used as a biomarker of muscle abnormalities in neurogenic and myopathic diseases. EIM has yet to be evaluated in the tongue musculature in patients with amyotrophic lateral sclerosis (ALS), who often show clinical bulbar signs.\n                    <jats:italic>Methods<\/jats:italic>\n                    : The lingual musculature of 19 subjects with motor neuron disease and 21 normal participants was assessed using EIM, strength and endurance testing, and clinical assessment.\n                    <jats:italic>Results<\/jats:italic>\n                    : Tongue musculature in the ALS group was characterized by significantly smaller phase (Ph) and greater resistance (R) when compared with the healthy cohort. Ph and tongue endurance were correlated in the ALS group.\n                    <jats:italic>Conclusions<\/jats:italic>\n                    : EIM of tongue musculature could distinguish those with ALS from healthy controls. The demonstrated relationship between tongue function and Ph supports further testing of EIM of the tongue as a potential biomarker in ALS.\n                    <jats:italic>Muscle Nerve<\/jats:italic>\n                    52: 584\u2013591, 2015\n                  <\/jats:p>","DOI":"10.1002\/mus.24565","type":"journal-article","created":{"date-parts":[[2015,1,11]],"date-time":"2015-01-11T21:09:42Z","timestamp":1421010582000},"page":"584-591","source":"Crossref","is-referenced-by-count":35,"title":["Electrical impedance myography in the evaluation of the tongue musculature in amyotrophic lateral sclerosis"],"prefix":"10.1002","volume":"52","author":[{"given":"Sanjana","family":"Shellikeri","sequence":"first","affiliation":[{"name":"Department of Speech\u2010Language Pathology University of Toronto Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yana","family":"Yunusova","sequence":"additional","affiliation":[{"name":"Department of Speech\u2010Language Pathology University of Toronto Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordan R.","family":"Green","sequence":"additional","affiliation":[{"name":"MGH Institute of Health Professions Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary L.","family":"Pattee","sequence":"additional","affiliation":[{"name":"Munroe\u2010Meyer Institute Nebraska Medical Center Omaha Nebraska USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James D.","family":"Berry","sequence":"additional","affiliation":[{"name":"Department of Neurology, MDA ALS Clinic Massachusetts General Hospital Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seward B.","family":"Rutkove","sequence":"additional","affiliation":[{"name":"Department of Neurology Harvard Medical School and Beth Israel Deaconess Medical Center Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorne","family":"Zinman","sequence":"additional","affiliation":[{"name":"ALS\/MND Clinic, Sunnybrook Health Sciences Centre, Department of Neurology University of Toronto Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,6,3]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000049472.47709.3B"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-510X(98)00196-8"},{"key":"e_1_2_6_4_1","first-page":"35","article-title":"Speech deterioration in amyotrophic lateral sclerosis: implications for the timing of intervention","volume":"1","author":"Yorkston KM","year":"1993","journal-title":"J Med Speech Lang Pathol"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.38.2.281"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1044\/jshr.3606.1158"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000265636"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1044\/jshr.3701.28"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.36.7.937"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0733-8619(18)30938-1"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.51.5.1417"},{"key":"e_1_2_6_12_1","first-page":"521","article-title":"Design of clinical therapeutic trials in amyotrophic lateral sclerosis","volume":"56","author":"Brooks BR","year":"1990","journal-title":"Adv Neurol"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(09)70030-4"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2007.08.004"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2011.06.002"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.3109\/17482968.2012.688837"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2009.04.007"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.20626"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1088\/0967-3334\/27\/10\/002"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2007.07.016"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1088\/0967-3334\/34\/12\/1611"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1532-5415.2003.51534.x"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/58.11.M1012"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.1215"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000343008.26874.d1"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.21075"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1088\/0022-3727\/40\/1\/S02"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1088\/0967-3334\/27\/12\/002"},{"key":"e_1_2_6_29_1","first-page":"173","volume-title":"Dysarthria and Apraxia of Speech: Perspectives on Management","author":"Robin DA","year":"1991"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1044\/jshr.3506.1239"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/51A.5.M247"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-510X(99)00210-5"},{"key":"e_1_2_6_33_1","unstructured":"NE 2007 Beukelman D Yorkston K Hakel M Dorsey M. Speech Intelligibility Test [computer software]. Madonna Rehabilitation Hospital Lincoln"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-510X(01)00623-2"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.3109\/21678421.2012.735238"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0045004"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2009.04.007"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00433.2003"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00455-011-9328-2"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1044\/jshr.2304.828"},{"key":"e_1_2_6_41_1","article-title":"Oral, pharyngeal and esophageal motor function in aging","author":"Robbins J","journal-title":"GI Motility Online"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410250508"},{"key":"e_1_2_6_43_1","first-page":"665","article-title":"MRI findings of the tongue in neurodegenerative diseases with bulbar sign","volume":"30","author":"Konagaya M","year":"1990","journal-title":"Rinsho Shinkeigaku Clin Neurol"},{"key":"e_1_2_6_44_1","first-page":"69","volume-title":"Neuromotor Speech Disorders: Nature, Assessment, and Management","author":"DePaul R","year":"1998"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/121.6.1099"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.3109\/21678421.2013.817585"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.21362"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.3109\/17482960802379004"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-009-2037-8_6"},{"key":"e_1_2_6_50_1","first-page":"812","article-title":"Functionally specific articulatory cooperation following jaw perturbations during speech: evidence for coordinative structures","volume":"10","author":"Kelso JS","year":"1984","journal-title":"J Exp Psychol"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1044\/jshr.3506.1239"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.1044\/jslhr.4301.256"},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/50A.5.M257"},{"key":"e_1_2_6_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9924(86)90015-8"},{"key":"e_1_2_6_55_1","doi-asserted-by":"publisher","DOI":"10.1044\/1092-4388(2004\/045)"},{"key":"e_1_2_6_56_1","first-page":"15","article-title":"Tongue strength and endurance in mild to moderate Parkinson's disease","volume":"3","author":"Solomon NP","year":"1995","journal-title":"J Med Speech Lang Pathol"},{"key":"e_1_2_6_57_1","doi-asserted-by":"publisher","DOI":"10.1044\/1092-4388(2011\/10-0258)"},{"key":"e_1_2_6_58_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/55.11.M634"},{"key":"e_1_2_6_59_1","doi-asserted-by":"publisher","DOI":"10.1044\/1092-4388(2009\/09-0048)"},{"key":"e_1_2_6_60_1","doi-asserted-by":"publisher","DOI":"10.1044\/1058-0360(2007\/019)"},{"key":"e_1_2_6_61_1","doi-asserted-by":"publisher","DOI":"10.3109\/17482968.2012.725416"}],"container-title":["Muscle &amp; Nerve"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmus.24565","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.24565","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T22:33:38Z","timestamp":1696545218000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mus.24565"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6,3]]},"references-count":60,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,10]]}},"alternative-id":["10.1002\/mus.24565"],"URL":"https:\/\/doi.org\/10.1002\/mus.24565","archive":["Portico"],"relation":{},"ISSN":["0148-639X","1097-4598"],"issn-type":[{"value":"0148-639X","type":"print"},{"value":"1097-4598","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6,3]]}}}