{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,7]],"date-time":"2023-10-07T11:41:25Z","timestamp":1696678885990},"reference-count":17,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,3,5]],"date-time":"2015-03-05T00:00:00Z","timestamp":1425513600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Malignant hyperthermia (MH) is a potentially lethal anesthesic complication. Pathological symptoms develop after exposure to triggering substances. It remains uncertain whether cellular alterations pre\u2010exist. Mechanical properties of isolated muscle bundles were examined before and after exposure to a triggering substance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>With prior written consent, muscle bundles of 12 MH\u2010susceptible (MHS) and 56 MH\u2010nonsusceptible (MHN) individuals were examined before and after exposure to incremental doses of caffeine. Mechanical properties (baseline tension, peak tension, time to peak tension, and relaxation time) were measured. Contraction and relaxation derivatives and contraction\u2013relaxation coupling were calculated and analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mechanical properties were not different between the groups before caffeine application. Caffeine increased peak tension in both groups and baseline tension only in MHS muscle bundles; relaxation time\/derivative and contraction\u2013relaxation coupling were prolonged.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Cellular changes seen in MH are not pre\u2010existing. Exposure to triggering substance impairs relaxation in MHS muscle. <jats:italic>Muscle Nerve<\/jats:italic> 52: 580\u2013583, 2015<\/jats:p><\/jats:sec>","DOI":"10.1002\/mus.24580","type":"journal-article","created":{"date-parts":[[2015,1,23]],"date-time":"2015-01-23T22:43:43Z","timestamp":1422053023000},"page":"580-583","source":"Crossref","is-referenced-by-count":0,"title":["Effect of caffeine on intrinsic mechanical properties of normal and malignant hyperthermia\u2010susceptible muscle"],"prefix":"10.1002","volume":"52","author":[{"given":"Thomas","family":"Metterlein","sequence":"first","affiliation":[{"name":"Department of Anesthesiology University Hospital Regensburg 93053 Regensburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edmund","family":"Hartung","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Klinikum Frankfurt (Oder) Frankfurt (Oder) Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norbert","family":"Roewer","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology University Hospital W\u00fcrzburg W\u00fcrzburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Anetseder","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Krankenhaus Landshut Achdorf Landshut Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,3,5]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00101-002-0314-9"},{"key":"e_1_2_7_3_1","doi-asserted-by":"crossref","first-page":"9310","DOI":"10.1016\/S0021-9258(19)76541-7","article-title":"Abnormal sarcoplasmic reticulum ryanodine receptor in malignant hyperthermia","volume":"263","author":"Mickelson JR","year":"1988","journal-title":"J Biol Chem"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/56.11.1267"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00101-008-1399-6"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1076\/apab.106.4.318.4375"},{"key":"e_1_2_7_7_1","first-page":"291","article-title":"A study of the contractility, biochemistry and morphology of an isolated preparation of human skeletal muscle","volume":"52","author":"Moulds RF","year":"1977","journal-title":"Clin Sci Mol Med"},{"key":"e_1_2_7_8_1","first-page":"13","article-title":"Biochemistry and molecular genetics of muscle diseases","volume":"29","author":"Deufel T","year":"1991","journal-title":"Eur J Clin Chem Clin Biochem"},{"key":"e_1_2_7_9_1","first-page":"543","article-title":"Contractility of isolated human skeletal muscle","volume":"48","author":"Brust M","year":"1967","journal-title":"Arch Phys Med Rehabil"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1982.243.1.C66"},{"key":"e_1_2_7_11_1","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1152\/physrev.1996.76.2.537","article-title":"Malignant hyperthermia: excitation\u2010contraction coupling, Ca2+ release channel, and cell Ca2+ regulation defects","volume":"76","author":"Mickelson JR","year":"1996","journal-title":"Physiol Rev"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1989.257.4.C781"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880060404"},{"key":"e_1_2_7_14_1","doi-asserted-by":"crossref","first-page":"68","DOI":"10.2527\/jas1974.39168x","article-title":"Isometric contractile properties of skeletal muscle from stress susceptible and stress resistant pigs","volume":"39","author":"Campion DR","year":"1974","journal-title":"J Anim Sci"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2253-5-8"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.20512"},{"key":"e_1_2_7_17_1","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1152\/jappl.1987.62.4.1392","article-title":"Role of intracellular pH in muscle fatigue","volume":"62","author":"Metzger JM","year":"1987","journal-title":"J Appl Physiol"},{"key":"e_1_2_7_18_1","doi-asserted-by":"crossref","first-page":"1950","DOI":"10.1152\/jappl.1988.65.5.1950","article-title":"Relaxation of the diaphragm muscle: influence of ryanodine and fatigue","volume":"65","author":"Herve P","year":"1988","journal-title":"J Appl Physiol"}],"container-title":["Muscle &amp; 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