{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T10:27:46Z","timestamp":1756463266952},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,8,12]],"date-time":"2015-08-12T00:00:00Z","timestamp":1439337600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p><jats:italic>Introduction<\/jats:italic>: Autoimmune polyglandular syndromes (APS) are a group of disorders characterized by the presence of autoimmune processes in several endocrine and non\u2010endocrine organs that are classified into 4 types. <jats:italic>Methods<\/jats:italic>: We describe the case of a woman affected with APS type 3 who presented initially with Hashimoto thyroiditis and pernicious anemia and subsequently developed autoimmune chronic urticaria, myasthenia gravis, and type 1 diabetes mellitus. <jats:italic>Results<\/jats:italic>: This patient had a combination of components of APS types 3b, 3a, and 3c. She was referred for evaluation of chronic spontaneous urticaria and subsequently developed severe generalized myasthenia gravis, which was apparently unmasked by antihistamines used to control urticaria. <jats:italic>Conclusions<\/jats:italic>: Patients with APS should have a more thorough evaluation to better clarify their autoimmune background. Early detection of autoantibodies and latent organ\u2010specific dysfunction may help physicians take appropriate action to prevent full\u2010blown disease. <jats:italic>Muscle Nerve<\/jats:italic> <jats:bold>52<\/jats:bold>:440\u2013444, 2015<\/jats:p>","DOI":"10.1002\/mus.24635","type":"journal-article","created":{"date-parts":[[2015,3,24]],"date-time":"2015-03-24T17:23:13Z","timestamp":1427217793000},"page":"440-444","source":"Crossref","is-referenced-by-count":6,"title":["Autoimmune spontaneous chronic urticaria and generalized myasthenia gravis in a patient with polyglandular autoimmune syndrome type 3"],"prefix":"10.1002","volume":"52","author":[{"given":"Sergio Umberto","family":"De Marchi","sequence":"first","affiliation":[{"name":"Unit of Internal Medicine, Department of Experimental and Clinical Medicine Santa Maria della Misericordia Academic Hospital, University of Udine Via Colugna 50 33100 Udine Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emanuela","family":"Cecchin","sequence":"additional","affiliation":[{"name":"Unit of Internal Medicine, Department of Experimental and Clinical Medicine Santa Maria della Misericordia Academic Hospital, University of Udine Via Colugna 50 33100 Udine Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio","family":"De Marchi","sequence":"additional","affiliation":[{"name":"Unit of Internal Medicine, Department of Experimental and Clinical Medicine Santa Maria della Misericordia Academic Hospital, University of Udine Via Colugna 50 33100 Udine Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,8,12]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra030158"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/NRL.0b013e3181945437"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.2298\/VSP1204358P"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.21466"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpn.2014.02.006"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2009.03256.x"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12056"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.01.043"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aller.2013.05.006"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-4975(94)90394-8"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1210\/edrv.23.3.0466"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1999.02815.x"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199306033282204"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2008.10.004"},{"key":"e_1_2_5_16_1","first-page":"121","volume-title":"Int J Neurosci","author":"Mao ZF","year":"2011"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.82.2.438"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1875-9114.1997.tb03085.x"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1997.00440250045006"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2005.12.041"},{"key":"e_1_2_5_21_1","first-page":"1717","article-title":"Autoimmune polyglandular syndrome in a woman of 51 years","volume":"18","author":"Innico G","year":"2014","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.22103"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11596-014-1378-x"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0455.2002.430407.x"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/MED.0b013e32836313eb"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2013.00249"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2010.05818.x"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.2009.02091.x"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2013.07.006"}],"container-title":["Muscle &amp; 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