{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T19:06:08Z","timestamp":1790708768389,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":92,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AG044615"],"award-info":[{"award-number":["AG044615"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL105355"],"award-info":[{"award-number":["HL105355"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle Nerve"],"published-print":{"date-parts":[[2015,7]]},"DOI":"10.1002\/mus.24641","type":"journal-article","created":{"date-parts":[[2015,3,24]],"date-time":"2015-03-24T12:06:14Z","timestamp":1427198774000},"page":"76-82","source":"Crossref","is-referenced-by-count":52,"title":["Analysis of muscle fiber clustering in the diaphragm muscle of sarcopenic mice"],"prefix":"10.1002","volume":"52","author":[{"given":"Sarah M.","family":"Greising","sequence":"first","affiliation":[{"name":"Department of Physiology and Biomedical Engineering; Mayo Clinic; 200 First Street SW, SMH Jo 4-184 Rochester Minnesota 55905 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan S.","family":"Medina-Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biomedical Engineering; Mayo Clinic; 200 First Street SW, SMH Jo 4-184 Rochester Minnesota 55905 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amrit K.","family":"Vasdev","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biomedical Engineering; Mayo Clinic; 200 First Street SW, SMH Jo 4-184 Rochester Minnesota 55905 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary C.","family":"Sieck","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biomedical Engineering; Mayo Clinic; 200 First Street SW, SMH Jo 4-184 Rochester Minnesota 55905 USA"},{"name":"Department of Anesthesiology; Mayo Clinic; Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos B.","family":"Mantilla","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biomedical Engineering; Mayo Clinic; 200 First Street SW, SMH Jo 4-184 Rochester Minnesota 55905 USA"},{"name":"Department of Anesthesiology; Mayo Clinic; Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,6,1]]},"reference":[{"key":"10.1002\/mus.24641-BIB0001|mus24641-cit-0001","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.jamda.2011.01.003","article-title":"Sarcopenia: an undiagnosed condition in older adults. Current consensus definition: prevalence, etiology, and consequences. International working group on sarcopenia","volume":"12","author":"Fielding","year":"2011","journal-title":"J Am Med Dir Assoc"},{"key":"10.1002\/mus.24641-BIB0002|mus24641-cit-0002","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.arr.2010.04.004","article-title":"Models of accelerated sarcopenia: critical pieces for solving the puzzle of age-related muscle atrophy","volume":"9","author":"Buford","year":"2010","journal-title":"Ageing Res Rev"},{"key":"10.1002\/mus.24641-BIB0003|mus24641-cit-0003","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1093\/gerona\/glt135","article-title":"Motor unit changes seen with skeletal muscle sarcopenia in oldest old rats","volume":"69","author":"Kung","year":"2014","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"10.1002\/mus.24641-BIB0004|mus24641-cit-0004","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.jamda.2014.02.002","article-title":"Motoneuron loss is associated with sarcopenia","volume":"15","author":"Drey","year":"2014","journal-title":"J Am Med Dir Assoc"},{"key":"10.1002\/mus.24641-BIB0005|mus24641-cit-0005","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.phrs.2013.03.003","article-title":"GLPG0492, a novel selective androgen receptor modulator, improves muscle performance in the exercised-mdx mouse model of muscular dystrophy","volume":"72","author":"Cozzoli","year":"2013","journal-title":"Pharmacol Res"},{"key":"10.1002\/mus.24641-BIB0006|mus24641-cit-0006","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1097\/WNP.0000000000000066","article-title":"Effect of age and gender on the number of motor units in healthy subjects estimated by the multipoint incremental MUNE method","volume":"31","author":"Gawel","year":"2014","journal-title":"J Clin Neurophysiol"},{"key":"10.1002\/mus.24641-BIB0007|mus24641-cit-0007","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/j.exger.2013.06.001","article-title":"Diaphragm muscle sarcopenia in aging mice","volume":"48","author":"Greising","year":"2013","journal-title":"Exp Gerontol"},{"key":"10.1002\/mus.24641-BIB0008|mus24641-cit-0008","doi-asserted-by":"crossref","first-page":"2191","DOI":"10.1016\/j.biocel.2013.05.016","article-title":"Muscle type and fiber type specificity in muscle wasting","volume":"45","author":"Ciciliot","year":"2013","journal-title":"Int J Biochem Cell Biol"},{"key":"10.1002\/mus.24641-BIB0009|mus24641-cit-0009","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/j.exger.2013.02.012","article-title":"The decline in skeletal muscle mass with aging is mainly attributed to a reduction in type II muscle fiber size","volume":"48","author":"Nilwik","year":"2013","journal-title":"Exp Gerontol"},{"key":"10.1002\/mus.24641-BIB0010|mus24641-cit-0010","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1152\/jn.1986.55.4.619","article-title":"Plasticity of medial gastrocnemius motor units following cordotomy in the cat","volume":"55","author":"Munson","year":"1986","journal-title":"J Neurophysiol"},{"key":"10.1002\/mus.24641-BIB0011|mus24641-cit-0011","first-page":"345","volume-title":"Handbook of physiology","author":"Burke","year":"1975"},{"key":"10.1002\/mus.24641-BIB0012|mus24641-cit-0012","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1002\/wsbm.1184","article-title":"Systems biology of skeletal muscle: fiber type as an organizing principle","volume":"4","author":"Greising","year":"2012","journal-title":"Wiley Interdiscip Rev Syst Biol Med"},{"key":"10.1002\/mus.24641-BIB0013|mus24641-cit-0013","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.resp.2013.06.025","article-title":"Impact of diaphragm muscle fiber atrophy on neuromotor control","volume":"189","author":"Mantilla","year":"2013","journal-title":"Respir Physiol Neurobiol"},{"key":"10.1002\/mus.24641-BIB0014|mus24641-cit-0014","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1152\/japplphysiol.01120.2002","article-title":"Invited review: mechanisms underlying motor unit plasticity in the respiratory system","volume":"94","author":"Mantilla","year":"2003","journal-title":"J Appl Physiol"},{"key":"10.1002\/mus.24641-BIB0015|mus24641-cit-0015","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1152\/jappl.1989.67.2.620","article-title":"Oxidative capacity and capillary density of diaphragm motor units","volume":"67","author":"Enad","year":"1989","journal-title":"J Appl Physiol"},{"key":"10.1002\/mus.24641-BIB0016|mus24641-cit-0016","doi-asserted-by":"crossref","first-page":"2179","DOI":"10.1152\/jappl.1996.80.6.2179","article-title":"Myosin phenotype and SDH enzyme variability among motor unit fibers","volume":"80","author":"Sieck","year":"1996","journal-title":"J Appl Physiol"},{"key":"10.1002\/mus.24641-BIB0017|mus24641-cit-0017","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/S0272-5231(21)00958-8","article-title":"Physiological effects of diaphragm muscle denervation and disuse","volume":"15","author":"Sieck","year":"1994","journal-title":"Clin Chest Med"},{"key":"10.1002\/mus.24641-BIB0018|mus24641-cit-0018","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1152\/jn.1988.59.3.1055","article-title":"Mechanical properties of muscle units in the cat diaphragm","volume":"59","author":"Fournier","year":"1988","journal-title":"J Neurophysiol"},{"key":"10.1002\/mus.24641-BIB0019|mus24641-cit-0019","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.resp.2011.10.015","article-title":"Structure-activity relationships in rodent diaphragm muscle fibers vs","volume":"180","author":"Sieck","year":"2012","journal-title":"neuromuscular junctions. Respir Physiol Neurobiol"},{"key":"10.1002\/mus.24641-BIB0020|mus24641-cit-0020","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/BF01739810","article-title":"Three myosin heavy chain isoforms in type 2 skeletal muscle fibres","volume":"10","author":"Schiaffino","year":"1989","journal-title":"J Muscle Res Cell Motil"},{"key":"10.1002\/mus.24641-BIB0021|mus24641-cit-0021","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1074\/jbc.M112.424663","article-title":"Tissue-specific role of the Na,K-ATPase alpha2 isozyme in skeletal muscle","volume":"288","author":"Radzyukevich","year":"2013","journal-title":"J Biol Chem"},{"key":"10.1002\/mus.24641-BIB0022|mus24641-cit-0022","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1152\/jappl.1997.82.4.1145","article-title":"Metabolic and phenotypic adaptations of diaphragm muscle fibers with inactivation","volume":"82","author":"Zhan","year":"1997","journal-title":"J Appl Physiol"},{"key":"10.1002\/mus.24641-BIB0023|mus24641-cit-0023","doi-asserted-by":"crossref","first-page":"1894","DOI":"10.1152\/jappl.1999.87.5.1894","article-title":"Force-calcium relationship depends on myosin heavy chain and troponin isoforms in rat diaphragm muscle fibers","volume":"87","author":"Geiger","year":"1999","journal-title":"J Appl Physiol"},{"key":"10.1002\/mus.24641-BIB0024|mus24641-cit-0024","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1152\/jn.1989.61.4.737","article-title":"Changes in properties of the medial gastrocnemius motor units in aging rats","volume":"61","author":"Kanda","year":"1989","journal-title":"J Neurophysiol"},{"key":"10.1002\/mus.24641-BIB0025|mus24641-cit-0025","doi-asserted-by":"crossref","first-page":"e28090","DOI":"10.1371\/journal.pone.0028090","article-title":"Striking denervation of neuromuscular junctions without lumbar motoneuron loss in geriatric mouse muscle","volume":"6","author":"Chai","year":"2011","journal-title":"PloS One"},{"key":"10.1002\/mus.24641-BIB0026|mus24641-cit-0026","doi-asserted-by":"crossref","first-page":"e29082","DOI":"10.1371\/journal.pone.0029082","article-title":"Denervation causes fiber atrophy and myosin heavy chain co-expression in senescent skeletal muscle","volume":"7","author":"Rowan","year":"2012","journal-title":"PloS One"},{"key":"10.1002\/mus.24641-BIB0027|mus24641-cit-0027","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1002\/mus.880010205","article-title":"Motor innervation and fiber type pattern in amyotrophic lateral sclerosis and in Charcot-Marie-Tooth disease","volume":"1","author":"Telerman-Toppet","year":"1978","journal-title":"Muscle Nerve"},{"key":"10.1002\/mus.24641-BIB0028|mus24641-cit-0028","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1002\/mus.20755","article-title":"Frequent atrophic groups with mixed-type myofibers is distinctive to motor neuron syndromes","volume":"36","author":"Baloh","year":"2007","journal-title":"Muscle Nerve"},{"key":"10.1002\/mus.24641-BIB0029|mus24641-cit-0029","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0304-3959(00)00276-1","article-title":"Spared nerve injury: an animal model of persistent peripheral neuropathic pain","volume":"87","author":"Decosterd","year":"2000","journal-title":"Pain"},{"key":"10.1002\/mus.24641-BIB0030|mus24641-cit-0030","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1212\/WNL.18.7.681","article-title":"Correlative histochemical study of skeletal muscle after suprasegmental denervation, peripheral nerve section, and skeletal fixation","volume":"18","author":"Karpati","year":"1968","journal-title":"Neurology"},{"key":"10.1002\/mus.24641-BIB0031|mus24641-cit-0031","first-page":"251","article-title":"The motor unit: anatomy and histochemical functional correlations","volume":"97","author":"Kugelberg","year":"1976","journal-title":"Riv Patol Nerv Ment"},{"key":"10.1002\/mus.24641-BIB0032|mus24641-cit-0032","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1055\/s-2007-1006630","article-title":"Is axonal sprouting able to traverse the conjunctival layers of the peripheral nerve? A behavioral, motor, and sensory study of end-to-side nerve anastomosis","volume":"12","author":"Bertelli","year":"1996","journal-title":"J Reconstr Microsurg"},{"key":"10.1002\/mus.24641-BIB0033|mus24641-cit-0033","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1111\/j.1460-9568.2005.03954.x","article-title":"Type grouping in skeletal muscles after experimental reinnervation: another explanation","volume":"21","author":"Vleggeert-Lankamp","year":"2005","journal-title":"Eur J Neurosci"},{"key":"10.1002\/mus.24641-BIB0034|mus24641-cit-0034","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1152\/jappl.1995.79.5.1640","article-title":"Myoneural interactions affect diaphragm muscle adaptations to inactivity","volume":"79","author":"Miyata","year":"1995","journal-title":"J Appl Physiol"},{"key":"10.1002\/mus.24641-BIB0035|mus24641-cit-0035","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1152\/jappl.1992.72.1.293","article-title":"Effect of corticosteroids on diaphragm fatigue, SDH activity, and muscle fiber size","volume":"72","author":"Lewis","year":"1992","journal-title":"J Appl Physiol"},{"key":"10.1002\/mus.24641-BIB0036|mus24641-cit-0036","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1152\/japplphysiol.01122.2012","article-title":"Prolonged C2 spinal hemisection-induced inactivity reduces diaphragm muscle specific force with modest, selective atrophy of type IIx and\/or IIb fibers","volume":"114","author":"Mantilla","year":"2013","journal-title":"J Appl Physiol"},{"key":"10.1002\/mus.24641-BIB0037|mus24641-cit-0037","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/j.exger.2013.06.001","article-title":"Diaphragm muscle sarcopenia in aging mice","volume":"48","author":"Greising","year":"2013","journal-title":"Exp Gerontol"},{"key":"10.1002\/mus.24641-BIB0038|mus24641-cit-0038","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1152\/jappl.2000.89.2.695","article-title":"Maximum specific force depends on myosin heavy chain content in rat diaphragm muscle fibers","volume":"89","author":"Geiger","year":"2000","journal-title":"J Appl Physiol"},{"key":"10.1002\/mus.24641-BIB0039|mus24641-cit-0039","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1152\/japplphysiol.00095.2001","article-title":"Effects of hypothyroidism on maximum specific force in rat diaphragm muscle fibers","volume":"92","author":"Geiger","year":"2002","journal-title":"J Appl Physiol"},{"key":"10.1002\/mus.24641-BIB0040|mus24641-cit-0040","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1152\/jappl.2001.90.4.1196","article-title":"Effect of unilateral denervation on maximum specific force in rat diaphragm muscle fibers","volume":"90","author":"Geiger","year":"2001","journal-title":"J Appl Physiol"},{"key":"10.1002\/mus.24641-BIB0041|mus24641-cit-0041","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.resp.2009.09.002","article-title":"Neuromuscular adaptations to respiratory muscle inactivity","volume":"169","author":"Mantilla","year":"2009","journal-title":"Respir Physiol Neurobiol"}],"container-title":["Muscle & Nerve"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmus.24641","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/mus.24641","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,3]],"date-time":"2022-05-03T15:53:40Z","timestamp":1651593220000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mus.24641"}},"subtitle":["Fiber Type Clustering in Sarcopenia"],"short-title":[],"issued":{"date-parts":[[2015,6,1]]},"references-count":41,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,7]]}},"URL":"https:\/\/doi.org\/10.1002\/mus.24641","relation":{},"ISSN":["0148-639X"],"issn-type":[{"value":"0148-639X","type":"print"}],"subject":[],"published":{"date-parts":[[2015,6,1]]}}}