{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T07:05:15Z","timestamp":1763017515568},"reference-count":31,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,10,10]],"date-time":"2015-10-10T00:00:00Z","timestamp":1444435200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"ISIS","award":["396443-CS2"],"award-info":[{"award-number":["396443-CS2"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p><jats:italic>Introduction<\/jats:italic>: With clinical trials underway, our objective was to construct a composite score of global function that could discriminate among people with spinal muscular atrophy (SMA). <jats:italic>Methods<\/jats:italic>: Data were collected from 126 participants with SMA types 2 and 3. Scores from the Hammersmith Functional Motor Scale\u2014Expanded and Upper Limb Module were expressed as a percentage of the maximum score and 6\u2010minute walk test as percent of predicted normal distance. A principal component analysis was performed on the correlation matrix for the 3 percentage scores. <jats:italic>Results<\/jats:italic>: The first principal component yielded a composite score with approximately equal weighting of the 3 components and accounted for 82% of the total variability. The SMA functional composite score, an unweighted average of the 3 individual percentage scores, correlated almost perfectly with the first principal component. <jats:italic>Conclusions<\/jats:italic>: This combination of measures broadens the spectrum of ability that can be quantified in type 2 and 3 SMA patients. <jats:italic>Muscle Nerve<\/jats:italic> <jats:bold>52<\/jats:bold>: 942\u2013947, 2015<\/jats:p>","DOI":"10.1002\/mus.24670","type":"journal-article","created":{"date-parts":[[2015,4,3]],"date-time":"2015-04-03T23:29:25Z","timestamp":1428103765000},"page":"942-947","source":"Crossref","is-referenced-by-count":30,"title":["Spinal muscular atrophy functional composite score: A functional measure in spinal muscular atrophy"],"prefix":"10.1002","volume":"52","author":[{"given":"Jacqueline","family":"Montes","sequence":"first","affiliation":[{"name":"Department of Neurology Columbia University Medical Center 180 Ft. 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