{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T01:32:37Z","timestamp":1789263157453,"version":"build-2803163510"},"reference-count":47,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,11,23]],"date-time":"2015-11-23T00:00:00Z","timestamp":1448236800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Federico Foundation"},{"name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de Ensino Superior"},{"name":"Funda\u00e7\u00e3o do Amparo \u0300 Pesquisa do Estado de S\u00e3o Paulo"},{"name":"N\u00facleo de Apoio \u00e0 Pesquisa \u201cSa\u00fade da Crian\u00e7a e do Adolescente\u201d da USP"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Introduction<\/jats:italic>\n                    : It has been suggested that creatine supplementation is safe and effective for treating idiopathic inflammatory myopathies, but no pediatric study has been conducted to date. The objective of this study was to examine the efficacy and safety of creatine supplementation in juvenile dermatomyositis (JDM) patients.\n                    <jats:italic>Methods<\/jats:italic>\n                    : In this study, JDM patients received placebo or creatine supplementation (0.1 g\/kg\/day) in a randomized, crossover, double\u2010blind design. Subjects were assessed at baseline and after 12 weeks. The primary outcome was muscle function. Secondary outcomes included body composition, aerobic conditioning, health\u2010related quality of life, and muscle phosphocreatine (PCr) content. Safety was assessed by laboratory parameters and kidney function measurements.\n                    <jats:italic>Results<\/jats:italic>\n                    : Creatine supplementation did not affect muscle function, intramuscular PCr content, or any other secondary outcome. Kidney function was not affected, and no side effects were reported.\n                    <jats:italic>Conclusions<\/jats:italic>\n                    : Twelve weeks of creatine supplementation in JDM patients were well\u2010tolerated and free of adverse effects, but treatment did not affect muscle function, intramuscular PCr, or any other parameter.\n                    <jats:italic>Muscle Nerve<\/jats:italic>\n                    <jats:bold>53<\/jats:bold>\n                    : 58\u201366, 2016\n                  <\/jats:p>","DOI":"10.1002\/mus.24681","type":"journal-article","created":{"date-parts":[[2015,4,21]],"date-time":"2015-04-21T19:03:19Z","timestamp":1429642999000},"page":"58-66","source":"Crossref","is-referenced-by-count":32,"title":["Efficacy and safety of creatine supplementation in juvenile dermatomyositis: A randomized, double\u2010blind, placebo\u2010controlled crossover trial"],"prefix":"10.1002","volume":"53","author":[{"given":"Marina 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