{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T19:45:36Z","timestamp":1787859936083,"version":"build-2784847793"},"reference-count":31,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,6,1]],"date-time":"2015-06-01T00:00:00Z","timestamp":1433116800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"crossref","award":["Scientific Research (C-21500633 to Y.Oi., and S-19100009 and 24650407 to Y.Oh.)"],"award-info":[{"award-number":["Scientific Research (C-21500633 to Y.Oi., and S-19100009 and 24650407 to Y.Oh.)"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Introduction:<\/jats:italic>\n                    We investigated heat\u2010stress effects on the adult myosin heavy chain (MyHC) profile of soleus muscle fibers at an early stage of regeneration.\n                    <jats:italic>Methods:<\/jats:italic>\n                    Regenerating fibers in adult rats were analyzed 2, 4, or 6 days after bupivacaine injection. Rats were heat stressed by immersion in water (42\u2009\u00b1\u20091\u00b0C) for 30 minutes 24 hours after bupivacaine injection and every other day thereafter.\n                    <jats:italic>Results:<\/jats:italic>\n                    No adult MyHC isoforms were observed after 2 days, whereas some fibers expressed only fast MyHC after 4 days. Heat stress increased fast and slow MyHC in regenerating fibers after 6 days. Regenerating fibers expressing only slow MyHC were observed only in heat\u2010stressed muscles. Bupivacaine injection increased the number of Pax7\n                    <jats:sup>+<\/jats:sup>\n                    and MyoD\n                    <jats:sup>+<\/jats:sup>\n                    satellite cells in regenerating fibers, more so in heat\u2010stressed rats.\n                    <jats:italic>Conclusion:<\/jats:italic>\n                    The results indicate that heat stress accelerates fast\u2010to\u2010slow MyHC phenotype conversion in regenerating fibers via activation of satellite cells.\n                    <jats:italic>Muscle Nerve<\/jats:italic>\n                    <jats:bold>52<\/jats:bold>\n                    : 1047\u20131056, 2015\n                  <\/jats:p>","DOI":"10.1002\/mus.24686","type":"journal-article","created":{"date-parts":[[2015,4,21]],"date-time":"2015-04-21T19:06:54Z","timestamp":1429643214000},"page":"1047-1056","source":"Crossref","is-referenced-by-count":13,"title":["Heat\u2010Stress effects on the myosin heavy chain phenotype of rat soleus fibers during the early stages of regeneration"],"prefix":"10.1002","volume":"52","author":[{"given":"Yasuharu","family":"Oishi","sequence":"first","affiliation":[{"name":"Laboratory of Muscle Physiology Faculty of Education, Kumamoto University  Kumamoto 860\u20108555 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland R.","family":"Roy","sequence":"additional","affiliation":[{"name":"Department of Integrative Biology and Physiology and Brain Research Institute University of California Los Angeles Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomonori","family":"Ogata","sequence":"additional","affiliation":[{"name":"Faculty of Human Environmental Studies Hiroshima\u2010Shudo University  Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshinobu","family":"Ohira","sequence":"additional","affiliation":[{"name":"Research Center for Adipocyte &amp; Muscle Science Doshisha University Kyotanabe City Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,6]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"721","volume-title":"Neuromuscular adaptations to actual and simulated spaceflight. 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