{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T04:59:59Z","timestamp":1784091599608,"version":"3.55.0"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,6,3]],"date-time":"2015-06-03T00:00:00Z","timestamp":1433289600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p><jats:italic>Introduction<\/jats:italic>: In previous studies of myasthenia gravis (MG), increased mortality has been reported. The aim of this study was to estimate mortality in patients with acetylcholine receptor antibody\u2013positive (AChR\u2010Ab\u2013seropositive) MG in a nationwide population\u2013based, long\u2010term follow\u2010up study. <jats:italic>Methods:<\/jats:italic> All AChR\u2010Ab\u2013seropositive MG patients, diagnosed between 1985 and 2005, were identified. Defined by age at diagnosis (\u226450 or &gt;50 years), patients were classified as having early\u2010 or late\u2010onset MG. For comparison, 10 non\u2010MG individuals from the general population were matched with each patient. All patients and controls were followed until January 1, 2009. Mortality rates and estimated mortality rate ratios (MRRs) were calculated. <jats:italic>Results:<\/jats:italic> Of 702 AChR\u2010Ab\u2013seropositive MG patients, 302 died during follow\u2010up. Overall mortality was higher for patients with MG (MRR\u2009=\u20091.41, range 1.24\u20131.60). In late\u2010onset women and men, the MRRs were 1.64 (1.36\u20131.99) and 1.22 (1.02\u20131.46), respectively. Total MRR was highest during the first 5 years after diagnosis. <jats:italic>Conclusions:<\/jats:italic> MG diagnosis is still associated with increased mortality. <jats:italic>Muscle Nerve<\/jats:italic> <jats:bold>53<\/jats:bold>: 73\u201377, 2016<\/jats:p>","DOI":"10.1002\/mus.24697","type":"journal-article","created":{"date-parts":[[2015,4,25]],"date-time":"2015-04-25T15:33:05Z","timestamp":1429975985000},"page":"73-77","source":"Crossref","is-referenced-by-count":59,"title":["Mortality in myasthenia gravis: A nationwide population\u2013based follow\u2010up study in Denmark"],"prefix":"10.1002","volume":"53","author":[{"given":"Julie S.","family":"Hansen","sequence":"first","affiliation":[{"name":"Department of Neurology Aarhus University Hospital N\u00f8rrebrogade 44, byg 10 8000 Aarhus C Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ditte H.","family":"Danielsen","sequence":"additional","affiliation":[{"name":"Department of Neurology Aarhus University Hospital N\u00f8rrebrogade 44, byg 10 8000 Aarhus C Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Finn E.","family":"Somnier","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry, Immunology and Genetics Statens Serum Institute Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trine","family":"Fr\u00f8slev","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Jakobsen","sequence":"additional","affiliation":[{"name":"Department of Neurology Aarhus University Hospital N\u00f8rrebrogade 44, byg 10 8000 Aarhus C Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00f8ren P.","family":"Johnsen","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henning","family":"Andersen","sequence":"additional","affiliation":[{"name":"Department of Neurology Aarhus University Hospital N\u00f8rrebrogade 44, byg 10 8000 Aarhus C Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,6,3]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199406233302507"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(09)70063-8"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)05186-2"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000212371"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1586\/eci.12.34"},{"key":"e_1_2_6_7_1","first-page":"733","article-title":"Epidemiology of myasthenia gravis in Denmark","volume":"48","author":"Somnier FE","year":"1994","journal-title":"A longitudinal and comprehensive population survey. 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