{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T07:50:25Z","timestamp":1769500225068,"version":"3.49.0"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,12,23]],"date-time":"2015-12-23T00:00:00Z","timestamp":1450828800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p><jats:italic>Introduction<\/jats:italic>: Duchenne muscular dystrophy (DMD) is a degenerative disease of skeletal, respiratory, and cardiac muscles caused by defects in the dystrophin gene. More recently, brain involvement has been verified. Mitochondrial dysfunction and oxidative stress may underlie the pathophysiology of DMD. In this study we evaluate Krebs cycle enzymes activity in the cerebral cortex, diaphragm, and quadriceps muscles of <jats:italic>mdx<\/jats:italic> mice. <jats:italic>Methods<\/jats:italic>: Cortex, diaphragm, and quadriceps tissues from male dystrophic <jats:italic>mdx<\/jats:italic> and control mice were used. <jats:italic>Results<\/jats:italic>: We observed increased malate dehydrogenase activity in the cortex; increased malate dehydrogenase and succinate dehydrogenase activities in the diaphragm; and increased citrate synthase, isocitrate dehydrogenase, and malate dehydrogenase activities in the quadriceps of <jats:italic>mdx<\/jats:italic> mice. <jats:italic>Conclusion<\/jats:italic>: This study showed increased activity of Krebs cycle enzymes in cortex, quadriceps, and diaphragm in <jats:italic>mdx<\/jats:italic> mice. <jats:italic>Muscle Nerve<\/jats:italic> <jats:bold>53<\/jats:bold>: 91\u201395, 2016<\/jats:p>","DOI":"10.1002\/mus.24704","type":"journal-article","created":{"date-parts":[[2015,5,12]],"date-time":"2015-05-12T12:22:48Z","timestamp":1431433368000},"page":"91-95","source":"Crossref","is-referenced-by-count":10,"title":["Activity of Krebs cycle enzymes in <i>mdx<\/i> mice"],"prefix":"10.1002","volume":"53","author":[{"given":"Clarissa M.","family":"Comim","sequence":"first","affiliation":[{"name":"Laboratory of Experimental Neuroscience, Postgraduate Program in Health Sciences University of Southern Santa Catarina Palho\u00e7a Santa Catarina Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreza","family":"Hoepers","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Neuroscience, Postgraduate Program in Health Sciences University of Southern Santa Catarina Palho\u00e7a Santa Catarina 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