{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T13:14:56Z","timestamp":1784121296535,"version":"3.55.0"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"name":"The Prinses Beatrix Spierfonds","award":["WAR09-01"],"award-info":[{"award-number":["WAR09-01"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle Nerve"],"published-print":{"date-parts":[[2016,2]]},"DOI":"10.1002\/mus.24712","type":"journal-article","created":{"date-parts":[[2015,5,27]],"date-time":"2015-05-27T14:08:53Z","timestamp":1432735733000},"page":"227-233","source":"Crossref","is-referenced-by-count":11,"title":["Identifying fasciculation potentials in motor neuron disease: A matter of probability"],"prefix":"10.1002","volume":"53","author":[{"given":"Boudewijn T.H.M.","family":"Sleutjes","sequence":"first","affiliation":[{"name":"Department of Clinical Neurophysiology; Erasmus MC, University Medical Centre Rotterdam; P.O. Box 2040 3000 CA Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan","family":"Gligorijevi\u0107","sequence":"additional","affiliation":[{"name":"Department of Electrical Engineering; SCD-SISTA; KU Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inger","family":"Montfoort","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurophysiology; Erasmus MC, University Medical Centre Rotterdam; P.O. Box 2040 3000 CA Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pieter A.","family":"van Doorn","sequence":"additional","affiliation":[{"name":"Department of Neurology; Erasmus MC, University Medical Centre Rotterdam; The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerhard H.","family":"Visser","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurophysiology; SEIN Heemstede; The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joleen H.","family":"Blok","sequence":"additional","affiliation":[{"name":"Department of Clinical Physics; M\u00e1xima Medical Centre; Veldhoven The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,10,10]]},"reference":[{"issue":"Suppl 1","key":"10.1002\/mus.24712-BIB0001|mus24712-cit-0001","doi-asserted-by":"crossref","first-page":"S43","DOI":"10.1016\/S0022-510X(97)00243-8","article-title":"Fasciculations: what do we know of their significance?","volume":"152","author":"Desai","year":"1997","journal-title":"J Neurol Sci"},{"key":"10.1002\/mus.24712-BIB0002|mus24712-cit-0002","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1002\/mus.880151104","article-title":"Surface EMG in the recording of fasciculations","volume":"15","author":"Howard","year":"1992","journal-title":"Muscle Nerve"},{"key":"10.1002\/mus.24712-BIB0003|mus24712-cit-0003","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/0168-5597(94)90036-1","article-title":"Fasciculation potentials in foot and leg muscles of healthy young adults","volume":"93","author":"Heijden","year":"1994","journal-title":"Electroencephalogr Clin Neurophysiol"},{"key":"10.1002\/mus.24712-BIB0004|mus24712-cit-0004","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.clinph.2007.09.143","article-title":"Electrodiagnostic criteria for diagnosis of ALS","volume":"119","author":"Carvalho","year":"2008","journal-title":"Clin Neurophysiol"},{"key":"10.1002\/mus.24712-BIB0005|mus24712-cit-0005","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1002\/mus.21180","article-title":"Needle electromyography","volume":"39","author":"Daube","year":"2009","journal-title":"Muscle Nerve"},{"issue":"Suppl 2","key":"10.1002\/mus.24712-BIB0006|mus24712-cit-0006","first-page":"ii32","article-title":"The basics of electromyography","volume":"76","author":"Mills","year":"2005","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1002\/mus.24712-BIB0007|mus24712-cit-0007","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/S0733-8619(01)00005-6","article-title":"Needle electromyography. Fundamentals, normal and abnormal patterns","volume":"20","author":"Preston","year":"2002","journal-title":"Neurol Clin"},{"key":"10.1002\/mus.24712-BIB0008|mus24712-cit-0008","doi-asserted-by":"crossref","first-page":"3458","DOI":"10.1093\/brain\/awq290","article-title":"Characteristics of fasciculations in amyotrophic lateral sclerosis and the benign fasciculation syndrome","volume":"133","author":"Mills","year":"2010","journal-title":"Brain"},{"key":"10.1002\/mus.24712-BIB0009|mus24712-cit-0009","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1212\/01.wnl.0000300559.14806.2a","article-title":"Firing pattern of fasciculations in ALS: evidence for axonal and neuronal origin","volume":"70","author":"Kleine","year":"2008","journal-title":"Neurology"},{"key":"10.1002\/mus.24712-BIB0010|mus24712-cit-0010","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1002\/(SICI)1097-4598(199803)21:3<336::AID-MUS7>3.0.CO;2-B","article-title":"Fasciculation potentials: a study of amyotrophic lateral sclerosis and other neurogenic disorders","volume":"21","author":"Carvalho","year":"1998","journal-title":"Muscle Nerve"},{"key":"10.1002\/mus.24712-BIB0011|mus24712-cit-0011","doi-asserted-by":"crossref","first-page":"066010","DOI":"10.1088\/1741-2560\/8\/6\/066010","article-title":"Characterizing the complexity of spontaneous motor unit patterns of amyotrophic lateral sclerosis using approximate entropy","volume":"8","author":"Zhou","year":"2011","journal-title":"J Neural Eng"},{"key":"10.1002\/mus.24712-BIB0012|mus24712-cit-0012","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1002\/mus.880050305","article-title":"Pathophysiology of fasciculations in ALS as studied by electromyography of single motor units","volume":"5","author":"Conradi","year":"1982","journal-title":"Muscle Nerve"},{"key":"10.1002\/mus.24712-BIB0013|mus24712-cit-0013","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1097\/00127893-200201000-00005","article-title":"The spectrum of ectopic motor nerve behavior: from fasciculations to neuromyotonia","volume":"8","author":"Caress","year":"2002","journal-title":"Neurologist"},{"key":"10.1002\/mus.24712-BIB0014|mus24712-cit-0014","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1002\/mus.20849","article-title":"Interspike interval analysis in a patient with peripheral nerve hyperexcitability and potassium channel antibodies","volume":"37","author":"Kleine","year":"2008","journal-title":"Muscle Nerve"},{"key":"10.1002\/mus.24712-BIB0015|mus24712-cit-0015","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1016\/j.jelekin.2008.09.001","article-title":"Motor unit tracking with high-density surface EMG","volume":"18","author":"Maathuis","year":"2008","journal-title":"J Electromyogr Kinesiol"},{"key":"10.1002\/mus.24712-BIB0016|mus24712-cit-0016","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1007\/s11517-012-1029-y","article-title":"A new and fast approach towards sEMG decomposition","volume":"51","author":"Gligorijevic","year":"2013","journal-title":"Med Biol Eng Comput"},{"issue":"Suppl","key":"10.1002\/mus.24712-BIB0017|mus24712-cit-0017","first-page":"S1","article-title":"American Association of Electrodiagnostic Medicine glossary of terms in electrodiagnostic medicine","volume":"10","year":"2001","journal-title":"Muscle Nerve"},{"issue":"Pt 1","key":"10.1002\/mus.24712-BIB0018|mus24712-cit-0018","first-page":"251","article-title":"Malignant and benign fasciculations","volume":"13","author":"Trojaborg","year":"1965","journal-title":"Acta Neurol Scand Suppl"},{"issue":"Suppl 1","key":"10.1002\/mus.24712-BIB0019|mus24712-cit-0019","doi-asserted-by":"crossref","first-page":"S53","DOI":"10.1080\/14660820052415916","article-title":"Fasciculations without fibrillations: the dilemma of early diagnosis","author":"Rosenfeld","year":"2000","journal-title":"Amyotroph Lateral Scler Other Motor Neuron Disord"},{"key":"10.1002\/mus.24712-BIB0020|mus24712-cit-0020","first-page":"237","article-title":"Two consecutive fasciculation potentials having different motor unit origins are an electromyographically pathognomonic finding of ALS","volume":"40","author":"Shiga","year":"2000","journal-title":"Electromyogr Clin Neurophysiol"},{"key":"10.1002\/mus.24712-BIB0021|mus24712-cit-0021","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.clinph.2013.06.014","article-title":"Sensitivity of MUP parameters in detecting change in early ALS","volume":"125","author":"Carvalho","year":"2014","journal-title":"Clin Neurophysiol"},{"key":"10.1002\/mus.24712-BIB0022|mus24712-cit-0022","doi-asserted-by":"crossref","first-page":"2312","DOI":"10.1016\/j.clinph.2012.04.016","article-title":"Motor unit firing in amyotrophic lateral sclerosis and other upper and lower motor neurone disorders","volume":"123","author":"Carvalho","year":"2012","journal-title":"Clin Neurophysiol"},{"key":"10.1002\/mus.24712-BIB0023|mus24712-cit-0023","doi-asserted-by":"crossref","first-page":"181","DOI":"10.3109\/17482960903062137","article-title":"Prevalence and distribution of fasciculations in healthy adults: effect of age, caffeine consumption and exercise","volume":"11","author":"Fermont","year":"2010","journal-title":"Amyotroph Lateral Scler"},{"key":"10.1002\/mus.24712-BIB0024|mus24712-cit-0024","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1002\/(SICI)1097-4598(199804)21:4<533::AID-MUS14>3.0.CO;2-Y","article-title":"Fasciculation potentials in healthy people","volume":"21","author":"Mitsikostas","year":"1998","journal-title":"Muscle Nerve"},{"key":"10.1002\/mus.24712-BIB0025|mus24712-cit-0025","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1186\/1743-0003-9-78","article-title":"Duration of observation required in detecting fasciculation potentials in amyotrophic lateral sclerosis using high-density surface EMG","volume":"9","author":"Zhou","year":"2012","journal-title":"J Neuroeng Rehabil"},{"key":"10.1002\/mus.24712-BIB0026|mus24712-cit-0026","doi-asserted-by":"crossref","first-page":"75","DOI":"10.3389\/fncel.2013.00075","article-title":"Motoneuron double discharges: only one or two different entities?","volume":"7","author":"Kudina","year":"2013","journal-title":"Front Cell Neurosci"},{"key":"10.1002\/mus.24712-BIB0027|mus24712-cit-0027","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/s004150050561","article-title":"Neurophysiological features of fasciculation potentials evoked by transcranial magnetic stimulation in amyotrophic lateral sclerosis","volume":"247","author":"Carvalho","year":"2000","journal-title":"J Neurol"},{"key":"10.1002\/mus.24712-BIB0028|mus24712-cit-0028","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/0013-4694(95)00166-2","article-title":"Abnormal excitability of the corticospinal pathway in patients with amyotrophic lateral sclerosis: a single motor unit study using transcranial magnetic stimulation","volume":"101","author":"Kohara","year":"1996","journal-title":"Electroencephalogr Clin Neurophysiol"},{"key":"10.1002\/mus.24712-BIB0029|mus24712-cit-0029","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1002\/(SICI)1097-4598(199701)20:1<65::AID-MUS9>3.0.CO;2-F","article-title":"Abnormalities of cortical inhibitory neurons in amyotrophic lateral sclerosis","volume":"20","author":"Enterzari-Taher","year":"1997","journal-title":"Muscle Nerve"}],"container-title":["Muscle &amp; Nerve"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmus.24712","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/mus.24712","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,5]],"date-time":"2021-07-05T04:58:01Z","timestamp":1625461081000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mus.24712"}},"subtitle":["Fasciculations in MND"],"short-title":[],"issued":{"date-parts":[[2015,10,10]]},"references-count":29,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,2]]}},"URL":"https:\/\/doi.org\/10.1002\/mus.24712","archive":["Portico"],"relation":{},"ISSN":["0148-639X"],"issn-type":[{"value":"0148-639X","type":"print"}],"subject":[],"published":{"date-parts":[[2015,10,10]]}}}