{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T09:23:48Z","timestamp":1789982628470,"version":"4.0.1"},"reference-count":15,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,7,24]],"date-time":"2015-07-24T00:00:00Z","timestamp":1437696000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000894","name":"SMA Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000894","id-type":"DOI","asserted-by":"crossref"}]},{"name":"SMA Europe"},{"name":"SMA Trust"},{"name":"Famiglie SMA"},{"name":"Telethon (Italy)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p><jats:italic>Introduction<\/jats:italic>: A recent Rasch analysis performed on the Hammersmith Functional Motor Scale\u2014Expanded (HFMSE) in patients with spinal muscular atrophy (SMA) identified issues impacting scale validity, redundant items, and disordered thresholds on some items. <jats:italic>Methods<\/jats:italic>: We modified the HMFSE scoring based on the Rasch analysis and on expert consensus to establish whether the traditional scoring overestimated the number of patients with changes within 2 points from baseline. Data were collected retrospectively from multicenter data sets in 255 type 2 and 3 SMA patients. <jats:italic>Results<\/jats:italic>: The mean 12\u2010month changes using the new and the traditional scoring system did not differ significantly (<jats:italic>P<\/jats:italic>\u2009&gt;\u20090.05). The numbers of patients who improved or decreased by &gt;2 points were also similar. <jats:italic>Conclusions<\/jats:italic>: The presence of outliers using the traditional scoring system was not due to overestimation of changes in activities that were tested bilaterally or to discrepancies in the scoring hierarchy of individual items. <jats:italic>Muscle Nerve<\/jats:italic> 52:435\u2013437, 2015<\/jats:p>","DOI":"10.1002\/mus.24748","type":"journal-article","created":{"date-parts":[[2015,6,26]],"date-time":"2015-06-26T00:41:22Z","timestamp":1435279282000},"page":"435-437","source":"Crossref","is-referenced-by-count":7,"title":["Old measures and new scores in spinal muscular atrophy patients"],"prefix":"10.1002","volume":"52","author":[{"given":"Elena","family":"Mazzone","sequence":"first","affiliation":[{"name":"Department of Paediatric Neurology Catholic University Largo Gemelli 8 00168 Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline","family":"Montes","sequence":"additional","affiliation":[{"name":"Department of Neurology Columbia University Medical Center New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marion","family":"Main","sequence":"additional","affiliation":[{"name":"Dubowitz Neuromuscular Centre UCL Institute of Child Health &amp; Great Ormond Street Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Mayhew","sequence":"additional","affiliation":[{"name":"Institute of Genetic Medicine Newcastle University Newcastle UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle","family":"Ramsey","sequence":"additional","affiliation":[{"name":"Dubowitz Neuromuscular Centre UCL Institute of Child Health &amp; Great Ormond Street Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allan M.","family":"Glanzman","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy The Children's Hospital of Philadelphia Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sally","family":"Dunaway","sequence":"additional","affiliation":[{"name":"Department of Neurology Columbia University Medical Center New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Salazar","sequence":"additional","affiliation":[{"name":"Department of Neurology Columbia University Medical Center New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Pasternak","sequence":"additional","affiliation":[{"name":"Department of Neurology Boston Children's Hospital, Harvard Medical School Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet","family":"Quigley","sequence":"additional","affiliation":[{"name":"Department of Neurology Boston Children's Hospital, Harvard Medical School Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marika","family":"Pane","sequence":"additional","affiliation":[{"name":"Department of Paediatric Neurology Catholic University Largo Gemelli 8 00168 Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria C.","family":"Pera","sequence":"additional","affiliation":[{"name":"Department of Paediatric Neurology Catholic University Largo Gemelli 8 00168 Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariacristina","family":"Scoto","sequence":"additional","affiliation":[{"name":"Dubowitz Neuromuscular Centre UCL Institute of Child Health &amp; Great Ormond Street Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Messina","sequence":"additional","affiliation":[{"name":"Department of Neurosciences University of Messina  Messina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Sframeli","sequence":"additional","affiliation":[{"name":"Department of Neurosciences University of Messina  Messina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adele","family":"D'amico","sequence":"additional","affiliation":[{"name":"Unit of Neuromuscular and Neurodegenerative Disorders Department of Neurosciences IRCCS Bambino Ges\u00f9 Children's Hospital Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marleen","family":"Van Den Hauwe","sequence":"additional","affiliation":[{"name":"Department of Child Neurology University Hospitals Leuven Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serena","family":"Sivo","sequence":"additional","affiliation":[{"name":"Department of Paediatric Neurology Catholic University Largo Gemelli 8 00168 Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Goemans","sequence":"additional","affiliation":[{"name":"Department of Child Neurology University Hospitals Leuven Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Basil T.","family":"Darras","sequence":"additional","affiliation":[{"name":"Department of Neurology Boston Children's Hospital, Harvard Medical School Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petra","family":"Kaufmann","sequence":"additional","affiliation":[{"name":"Department of Neurology Columbia University Medical Center New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico","family":"Bertini","sequence":"additional","affiliation":[{"name":"Unit of Neuromuscular and Neurodegenerative Disorders Department of Neurosciences IRCCS Bambino Ges\u00f9 Children's Hospital Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darryl C.","family":"De Vivo","sequence":"additional","affiliation":[{"name":"Department of Neurology Columbia University Medical Center New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Muntoni","sequence":"additional","affiliation":[{"name":"Dubowitz Neuromuscular Centre UCL Institute of Child Health &amp; 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