{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T17:59:57Z","timestamp":1791568797093,"version":"4.3.4"},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,1,27]],"date-time":"2016-01-27T00:00:00Z","timestamp":1453852800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"FDA Orphan Products Development","award":["R01FD003710"],"award-info":[{"award-number":["R01FD003710"]}]},{"name":"National Institutes of Health\/NCATS Institutional Clinical and Translational Science Award","award":["UL1TR000001"],"award-info":[{"award-number":["UL1TR000001"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Introduction<\/jats:italic>\n                    : In this study we evaluated the safety, tolerability, and efficacy of prednisone in patients with ocular myasthenia gravis (OMG) concurrently treated with pyridostigmine.\n                    <jats:italic>Methods<\/jats:italic>\n                    : This investigation was a randomized, double\u2010blind, placebo\u2010controlled trial. Participants whose symptoms failed to remit on pyridostigmine were randomized to receive placebo or prednisone, initiated at 10 mg every other day, and titrated to a maximum of 40 mg\/day over 16 weeks. The primary outcome measure was treatment failure.\n                    <jats:italic>Results<\/jats:italic>\n                    : Fewer subjects were randomized than the 88 planned. Of the 11 randomized, 9 completed 16 weeks of double\u2010blind therapy. Treatment failure incidence was 100% (95% CI 48%\u2013100%) in the placebo group (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20095) vs. 17% (95% CI 0%\u201364%) in the prednisone group,\n                    <jats:italic>P =<\/jats:italic>\n                    0.02 (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20096). Median time to sustained minimal manifestation status (MMS) was 14 weeks, requiring an average prednisone dose of 15 mg\/day. Adverse events were infrequent and generally mild in both groups.\n                    <jats:italic>Conclusions<\/jats:italic>\n                    : A strategy of low\u2010dose prednisone with gradual escalation appears to be safe, well\u2010tolerated, and effective in treating OMG.\n                    <jats:italic>Muscle Nerve<\/jats:italic>\n                    53: 363\u2013369, 2016\n                  <\/jats:p>","DOI":"10.1002\/mus.24769","type":"journal-article","created":{"date-parts":[[2015,7,14]],"date-time":"2015-07-14T12:52:50Z","timestamp":1436878370000},"page":"363-369","source":"Crossref","is-referenced-by-count":135,"title":["Efficacy of prednisone for the treatment of ocular myasthenia (EPITOME): A randomized, controlled trial"],"prefix":"10.1002","volume":"53","author":[{"given":"Michael","family":"Benatar","sequence":"first","affiliation":[{"name":"Department of Neurology Miller School of Medicine, University of Miami 1120 NW 14th Street, CRB 1318 Miami Florida 33136 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael P.","family":"Mcdermott","sequence":"additional","affiliation":[{"name":"Department of Neurology Miller School of Medicine, University of Miami 1120 NW 14th Street, CRB 1318 Miami Florida 33136 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald B.","family":"Sanders","sequence":"additional","affiliation":[{"name":"Department of Neurology Miller School of Medicine, University of Miami 1120 NW 14th Street, CRB 1318 Miami Florida 33136 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gil I.","family":"Wolfe","sequence":"additional","affiliation":[{"name":"Department of Neurology Miller School of Medicine, University of Miami 1120 NW 14th Street, CRB 1318 Miami Florida 33136 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard J.","family":"Barohn","sequence":"additional","affiliation":[{"name":"Department of Neurology Miller School of Medicine, University of Miami 1120 NW 14th Street, CRB 1318 Miami Florida 33136 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard J.","family":"Nowak","sequence":"additional","affiliation":[{"name":"Department of Neurology Miller School of Medicine, University of Miami 1120 NW 14th Street, CRB 1318 Miami Florida 33136 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Hehir","sequence":"additional","affiliation":[{"name":"Department of Neurology Miller School of Medicine, University of Miami 1120 NW 14th Street, CRB 1318 Miami Florida 33136 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vern","family":"Juel","sequence":"additional","affiliation":[{"name":"Department of Neurology Miller School of Medicine, University of Miami 1120 NW 14th Street, CRB 1318 Miami Florida 33136 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Katzberg","sequence":"additional","affiliation":[{"name":"Department of Neurology Miller School of Medicine, University of Miami 1120 NW 14th Street, CRB 1318 Miami Florida 33136 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rabi","family":"Tawil","sequence":"additional","affiliation":[{"name":"Department of Neurology Miller School of Medicine, University of Miami 1120 NW 14th Street, CRB 1318 Miami Florida 33136 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Muscle Study Group (MSG)","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,1,27]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(55)92480-6"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.20950"},{"key":"e_1_2_8_4_1","first-page":"113","volume-title":"Neuromuscular disorders","author":"Sanders D","year":"2011"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000109688"},{"key":"e_1_2_8_6_1","first-page":"CD005081","article-title":"Medical and surgical treatments for ocular myasthenia","volume":"12","author":"Benatar M","year":"2012","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410140504"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000080093"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1999.tb00733.x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1964.00460200010002"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.42.10.1888"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.65.4.492"},{"key":"e_1_2_8_13_1","doi-asserted-by":"crossref","unstructured":"Emilia\u2010Romagna Study Group on Clinical and Epidemiological Problems in Neurology. Incidence of myasthenia gravis in the Emilia\u2010Romagna region: a prospective multicenter study. 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